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Review

Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection

by 1, 1 and 1,2,*
1
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2
KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2110; https://doi.org/10.3390/ijms20092110
Received: 4 April 2019 / Revised: 25 April 2019 / Accepted: 26 April 2019 / Published: 29 April 2019
(This article belongs to the Special Issue Cytoplasmic Sensors: Infection, Inflammation, and Immunity)
Inflammasome activation is essential for host immune responses during pathogenic infection and sterile signals insult, whereas excessive activation is injurious. Thus, inflammasome activation is tightly regulated at multiple layers. Ubiquitination is an important post-translational modification for orchestrating inflammatory immune responses during pathogenic infection, and a major target hijacked by pathogenic bacteria for promoting their survival and proliferation. This review summarizes recent insights into distinct mechanisms of the inflammasome activation and ubiquitination process triggered by bacterial infection. We discuss the complex regulatory of inflammasome activation mediated by ubiquitination machinery during bacterial infection, and provide therapeutic approaches for specifically targeting aberrant inflammasome activation. View Full-Text
Keywords: inflammasome; ubiquitination; bacterial infection; immune response inflammasome; ubiquitination; bacterial infection; immune response
MDPI and ACS Style

Xu, T.; Guo, Y.; Qi, X. Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection. Int. J. Mol. Sci. 2019, 20, 2110. https://doi.org/10.3390/ijms20092110

AMA Style

Xu T, Guo Y, Qi X. Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection. International Journal of Molecular Sciences. 2019; 20(9):2110. https://doi.org/10.3390/ijms20092110

Chicago/Turabian Style

Xu, Tao, Yu Guo, and Xiaopeng Qi. 2019. "Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection" International Journal of Molecular Sciences 20, no. 9: 2110. https://doi.org/10.3390/ijms20092110

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