Next Article in Journal
Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer
Next Article in Special Issue
Mitochondria-Targeting Antioxidant Provides Cardioprotection through Regulation of Cytosolic and Mitochondrial Zn2+ Levels with Re-Distribution of Zn2+-Transporters in Aged Rat Cardiomyocytes
Previous Article in Journal
Expanding Genetic Code Expansion through Resource Facilities, Workshops, and Conferences
Previous Article in Special Issue
Zinc Supplementation Stimulates Red Blood Cell Formation in Rats
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 20
Issue 9
10.3390/ijms20092104
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Application of Acyzol in the Context of Zinc Deficiency and Perspectives

by
Gjumrakch Aliev
1,2,3,*,
Yi Li
4,
Vladimir N. Chubarev
1,
Svetlana A. Lebedeva
1,
Lidiya N. Parshina
5,
Boris A. Trofimov
5,
Susanna S. Sologova
1,
Alfiya Makhmutova
2,
Marco F. Avila-Rodriguez
6,
Sergey G. Klochkov
2,
Pavel A. Galenko-Yaroshevsky
7 and
Vadim V. Tarasov
1
1
Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia
2
Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia
3
GALLY International Research Institute, 7733 Louis Pasteur Drive #330, San Antonio, TX 78229, USA
4
Department of Biological and Health Sciences, Texas A&M University-Kingsville, TX 78363, USA
5
A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia
6
Universidad del Tolima, Facultad de Ciencias de la Salud, Barrio Santa Helena, Ibagué 730006, Colombia
7
Department of Pharmacology, Faculty of Pharmacy, Kuban State Medical University, 4 Sedin St., Krasnodar 350063, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2104; https://doi.org/10.3390/ijms20092104
Submission received: 5 April 2019 / Revised: 22 April 2019 / Accepted: 24 April 2019 / Published: 29 April 2019
(This article belongs to the Special Issue Zinc Biology 2019)
Browse Figures
Versions Notes

Abstract

Zinc is one of the most important essential trace elements. It is involved in more than 300 enzyme systems and is an indispensable participant in many biochemical processes. Zinc deficiency causes a number of disorders in the human body, the main ones being the delay of growth and puberty, immune disorders, and cognitive dysfunctions. There are over two billion people in the world suffering from zinc deficiency conditions. Acyzol, a zinc-containing medicine, developed as an antidote against carbon monoxide poisoning, demonstrates a wide range of pharmacological activities: Anti-inflammatory, reparative, detoxifying, immunomodulatory, bacteriostatic, hepatoprotective, adaptogenic, antioxidant, antihypoxic, and cardioprotective. The presence of zinc in the composition of Acyzol suggests the potential of the drug in the treatment and prevention of zinc deficiency conditions, such as Prasad’s disease, immune system pathology, alopecia, allergodermatoses, prostate dysfunction, psoriasis, stomatitis, periodontitis, and delayed mental and physical development in children. Currently, the efficiency of Acyzol in the cases of zinc deficiency is shown in a large number of experimental studies. So, Acyzol can be used as a highly effective drug for pharmacologic therapy of a wide range of diseases and conditions and it opens up new perspectives in the treatment and prevention of zinc deficiency conditions.
Keywords: Acyzol; carbon monoxide; pharmacological activity; zinc; zinc deficiency conditions Acyzol; carbon monoxide; pharmacological activity; zinc; zinc deficiency conditions

Share and Cite

MDPI and ACS Style

Aliev, G.; Li, Y.; Chubarev, V.N.; Lebedeva, S.A.; Parshina, L.N.; Trofimov, B.A.; Sologova, S.S.; Makhmutova, A.; Avila-Rodriguez, M.F.; Klochkov, S.G.; et al. Application of Acyzol in the Context of Zinc Deficiency and Perspectives. Int. J. Mol. Sci. 2019, 20, 2104. https://doi.org/10.3390/ijms20092104

AMA Style

Aliev G, Li Y, Chubarev VN, Lebedeva SA, Parshina LN, Trofimov BA, Sologova SS, Makhmutova A, Avila-Rodriguez MF, Klochkov SG, et al. Application of Acyzol in the Context of Zinc Deficiency and Perspectives. International Journal of Molecular Sciences. 2019; 20(9):2104. https://doi.org/10.3390/ijms20092104

Chicago/Turabian Style

Aliev, Gjumrakch, Yi Li, Vladimir N. Chubarev, Svetlana A. Lebedeva, Lidiya N. Parshina, Boris A. Trofimov, Susanna S. Sologova, Alfiya Makhmutova, Marco F. Avila-Rodriguez, Sergey G. Klochkov, and et al. 2019. "Application of Acyzol in the Context of Zinc Deficiency and Perspectives" International Journal of Molecular Sciences 20, no. 9: 2104. https://doi.org/10.3390/ijms20092104

APA Style

Aliev, G., Li, Y., Chubarev, V. N., Lebedeva, S. A., Parshina, L. N., Trofimov, B. A., Sologova, S. S., Makhmutova, A., Avila-Rodriguez, M. F., Klochkov, S. G., Galenko-Yaroshevsky, P. A., & Tarasov, V. V. (2019). Application of Acyzol in the Context of Zinc Deficiency and Perspectives. International Journal of Molecular Sciences, 20(9), 2104. https://doi.org/10.3390/ijms20092104

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop