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Int. J. Mol. Sci. 2019, 20(8), 1825;

When CAR Meets Stem Cells

School of Life Science, Handong Global University, Pohang 37554, Korea
Received: 26 March 2019 / Revised: 5 April 2019 / Accepted: 10 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue Stem Cell-Based Therapy)
PDF [1266 KB, uploaded 12 April 2019]


The generation of immune cells from human pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells) has been of keen interest to regenerative medicine. Pluripotent stem cell-derived immune cells such as natural killer cells, macrophages, and lymphoid cells, especially T cells, can be used in immune cell therapy to treat incurable cancers. Moreover, since the advent of chimeric antigen receptor (CAR) technology, the success of CAR-T cells in the clinic has galvanized new efforts to harness the power of CAR technology to generate CAR-engineered immune cells from pluripotent stem cells. This review provides a summary of pluripotent stem cell-derived immune cells and CAR technology, together with perspectives on combining pluripotent stem-cell derived immune cells and CAR engineering to pave a new way for developing next generation immune cell therapy. View Full-Text
Keywords: pluripotent stem cell; CAR; CRISPR/Cas9 pluripotent stem cell; CAR; CRISPR/Cas9

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Lee, J.M. When CAR Meets Stem Cells. Int. J. Mol. Sci. 2019, 20, 1825.

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