Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer

Kujundžić, Renata Novak; Stepanić, Višnja; Milković, Lidija; Gašparović, Ana Čipak; Tomljanović, Marko; Trošelj, Koraljka Gall

doi:10.3390/ijms20051180

Open AccessReview

Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer

by

Renata Novak Kujundžić

¹,

Višnja Stepanić

¹

,

Lidija Milković

²

,

Ana Čipak Gašparović

²

,

Marko Tomljanović

¹ and

Koraljka Gall Trošelj

^1,*

¹

Laboratory for Epigenomics, Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia

²

Laboratory for Oxidative Stress (LabOS), Ruđer Bošković Institute, Division of Molecular Medicine, 10 000 Zagreb, Croatia

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2019, 20(5), 1180; https://doi.org/10.3390/ijms20051180

Submission received: 25 January 2019 / Revised: 1 March 2019 / Accepted: 5 March 2019 / Published: 8 March 2019

(This article belongs to the Special Issue Curcumin in Health and Disease)

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Abstract

Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong possibility that its well-known anti-inflammatory properties may be relevant to this phenomenon. Curcumin’s binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin’s interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin. Our focus is on its modes of action that have the potential to alleviate specific morbidities of the 21st century.

Keywords: curcumin; oxidative metabolites; inflamm-aging; cancer; metabolic reprogramming; direct protein binding; IL-17; STAT3; SHMT2

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MDPI and ACS Style

Kujundžić, R.N.; Stepanić, V.; Milković, L.; Gašparović, A.Č.; Tomljanović, M.; Trošelj, K.G. Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer. Int. J. Mol. Sci. 2019, 20, 1180. https://doi.org/10.3390/ijms20051180

AMA Style

Kujundžić RN, Stepanić V, Milković L, Gašparović AČ, Tomljanović M, Trošelj KG. Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer. International Journal of Molecular Sciences. 2019; 20(5):1180. https://doi.org/10.3390/ijms20051180

Chicago/Turabian Style

Kujundžić, Renata Novak, Višnja Stepanić, Lidija Milković, Ana Čipak Gašparović, Marko Tomljanović, and Koraljka Gall Trošelj. 2019. "Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer" International Journal of Molecular Sciences 20, no. 5: 1180. https://doi.org/10.3390/ijms20051180

APA Style

Kujundžić, R. N., Stepanić, V., Milković, L., Gašparović, A. Č., Tomljanović, M., & Trošelj, K. G. (2019). Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer. International Journal of Molecular Sciences, 20(5), 1180. https://doi.org/10.3390/ijms20051180

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Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer

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