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Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin

1
Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Via S. Sofia 87, 95123 Catania, Italy
2
General and Emergency Surgery Department, Garibaldi Hospital, Piazza Santa Maria di Gesù, 95100 Catania, Italy
3
Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via Plebiscito 628, 95124 Catania, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(5), 1119; https://doi.org/10.3390/ijms20051119
Received: 25 January 2019 / Revised: 22 February 2019 / Accepted: 1 March 2019 / Published: 5 March 2019
(This article belongs to the Special Issue Curcumin in Health and Disease)
Wound healing implicates several biological and molecular events, such as coagulation, inflammation, migration-proliferation, and remodeling. Here, we provide an overview of the effects of malnutrition and specific nutrients on this process, focusing on the beneficial effects of curcumin. We have summarized that protein loss may negatively affect the whole immune process, while adequate intake of carbohydrates is necessary for fibroblast migration during the proliferative phase. Beyond micronutrients, arginine and glutamine, vitamin A, B, C, and D, zinc, and iron are essential for inflammatory process and synthesis of collagen. Notably, anti-inflammatory and antioxidant properties of curcumin might reduce the expression of tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) and restore the imbalance between reactive oxygen species (ROS) production and antioxidant activity. Since curcumin induces apoptosis of inflammatory cells during the early phase of wound healing, it could also accelerate the healing process by shortening the inflammatory phase. Moreover, curcumin might facilitate collagen synthesis, fibroblasts migration, and differentiation. Although curcumin could be considered as a wound healing agent, especially if topically administered, further research in wound patients is recommended to achieve appropriate nutritional approaches for wound management. View Full-Text
Keywords: wound; wound healing; diet; nutrition; micronutrients; macronutrients; curcumin; amino-acids; vitamins; minerals wound; wound healing; diet; nutrition; micronutrients; macronutrients; curcumin; amino-acids; vitamins; minerals
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MDPI and ACS Style

Barchitta, M.; Maugeri, A.; Favara, G.; Magnano San Lio, R.; Evola, G.; Agodi, A.; Basile, G. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Int. J. Mol. Sci. 2019, 20, 1119. https://doi.org/10.3390/ijms20051119

AMA Style

Barchitta M, Maugeri A, Favara G, Magnano San Lio R, Evola G, Agodi A, Basile G. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. International Journal of Molecular Sciences. 2019; 20(5):1119. https://doi.org/10.3390/ijms20051119

Chicago/Turabian Style

Barchitta, Martina; Maugeri, Andrea; Favara, Giuliana; Magnano San Lio, Roberta; Evola, Giuseppe; Agodi, Antonella; Basile, Guido. 2019. "Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin" Int. J. Mol. Sci. 20, no. 5: 1119. https://doi.org/10.3390/ijms20051119

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