Next Article in Journal
Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy
Next Article in Special Issue
Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1α Signaling Pathway
Previous Article in Journal
Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal
Previous Article in Special Issue
Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

Resveratrol as a Multifunctional Topical Hypopigmenting Agent

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 463-707, Korea
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(4), 956;
Received: 31 January 2019 / Revised: 11 February 2019 / Accepted: 18 February 2019 / Published: 22 February 2019
(This article belongs to the Special Issue Health Benefits of Resveratrol)
Melanin is produced in melanocytes and stored in melanosomes, after which it is transferred to keratinocytes and, thus, determines skin color. Despite its beneficial sun-protective effects, abnormal accumulation of melanin results in esthetic problems. A range of topical hypopigmenting agents have been evaluated for their use in the treatment of pigmentary disorders with varying degrees of success. Hydroquinone (HQ), which competes with tyrosine, is the main ingredient in topical pharmacological agents. However, frequent occurrence of adverse reactions is an important factor that limits its use. Thus, efforts to discover effective topical hypopigmenting agents with less adverse effects continue. Here, we describe the potential of resveratrol to function as an effective hypopigmenting agent based on its mechanism of action. Resveratrol is not only a direct tyrosinase inhibitor but an indirect inhibitor as well. Additionally, it can affect keratinocytes, which regulate the function of melanocytes. Resveratrol regulates the inflammatory process of keratinocytes and protects them from oxidative damage. In this way, it prevents keratinocyte-induced melanocyte stimulation. Furthermore, it has a rescuing effect on the stemness of interfollicular epidermal cells that can repair signs of photoaging in the melasma, a typical pigmentary skin disorder. Overall, resveratrol is a promising potent hypopigmenting agent. View Full-Text
Keywords: resveratrol; hypopigmenting agent; melanogenesis; tyrosinase inhibitor; antioxidant resveratrol; hypopigmenting agent; melanogenesis; tyrosinase inhibitor; antioxidant
Show Figures

Graphical abstract

MDPI and ACS Style

Na, J.-I.; Shin, J.-W.; Choi, H.-R.; Kwon, S.-H.; Park, K.-C. Resveratrol as a Multifunctional Topical Hypopigmenting Agent. Int. J. Mol. Sci. 2019, 20, 956.

AMA Style

Na J-I, Shin J-W, Choi H-R, Kwon S-H, Park K-C. Resveratrol as a Multifunctional Topical Hypopigmenting Agent. International Journal of Molecular Sciences. 2019; 20(4):956.

Chicago/Turabian Style

Na, Jung-Im, Jung-Won Shin, Hye-Ryung Choi, Soon-Hyo Kwon, and Kyung-Chan Park. 2019. "Resveratrol as a Multifunctional Topical Hypopigmenting Agent" International Journal of Molecular Sciences 20, no. 4: 956.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop