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Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal

1
College of Biopharmaceutical and Food Engineering, Shangluo University, Shangluo 726000, China
2
Department of Biology, Miami University, Oxford, OH 45056, USA
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Department of Automation, Xiamen University, Xiamen 361005, China
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Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, and College of the Environment and Ecology, Xiamen University, Xiamen 361102, China
5
Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 958; https://doi.org/10.3390/ijms20040958
Received: 26 January 2019 / Revised: 18 February 2019 / Accepted: 19 February 2019 / Published: 22 February 2019
(This article belongs to the Section Molecular Biology)
Pre-mRNA cleavage and polyadenylation is an essential step for almost all mRNA in eukaryotes. The cis-elements around the poly(A) sites, however, are very diverse among different organisms. We characterized the poly(A) signals of seven different species, and compared them with that of four well-studied organisms. We found that ciliates do not show any dominant poly(A) signal; a triplet (UAA) and tetramers (UAAA and GUAA) are dominant in diatoms and red alga, respectively; and green alga Ostreococcus uses UGUAA as its poly(A) signal. Spikemoss and moss use conserved AAUAAA signals that are similar to other land plants. Our analysis suggests that the first two bases (NN in NNUAAA) are likely degenerated whereas UAAA appears to be the core motif. Combined with other published results, it is suggested that the highly conserved poly(A) signal AAUAAA may be derived from UAA with an intermediate, putative UAAA, following a pathway of UAA→UAAA→AAUAAA. View Full-Text
Keywords: polyadenylation signal; RNA processing; mRNA 3′-end formation; bioinformatic analysis polyadenylation signal; RNA processing; mRNA 3′-end formation; bioinformatic analysis
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Zhao, Z.; Wu, X.; Ji, G.; Liang, C.; Li, Q.Q. Genome-Wide Comparative Analyses of Polyadenylation Signals in Eukaryotes Suggest a Possible Origin of the AAUAAA Signal. Int. J. Mol. Sci. 2019, 20, 958.

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