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In Search for the Membrane Regulators of Archaea
Open AccessReview

The Main (Glyco) Phospholipid (MPL) of Thermoplasma acidophilum

1
Goethe-Universität, Gustav-Embden-Zentrum, Laboratory of Microbiological Chemistry, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
2
Universitas Indonesia, Medical Research Unit, Faculty of Medicine, Jalan Salemba Raya 6, Jakarta 10430, Indonesia
Int. J. Mol. Sci. 2019, 20(20), 5217; https://doi.org/10.3390/ijms20205217
Received: 19 September 2019 / Revised: 15 October 2019 / Accepted: 18 October 2019 / Published: 21 October 2019
(This article belongs to the Special Issue Biochemistry and Biophysics of Archaea Membranes)
The main phospholipid (MPL) of Thermoplasma acidophilum DSM 1728 was isolated, purified and physico-chemically characterized by differential scanning calorimetry (DSC)/differential thermal analysis (DTA) for its thermotropic behavior, alone and in mixtures with other lipids, cholesterol, hydrophobic peptides and pore-forming ionophores. Model membranes from MPL were investigated; black lipid membrane, Langmuir-Blodgett monolayer, and liposomes. Laboratory results were compared to computer simulation. MPL forms stable and resistant liposomes with highly proton-impermeable membrane and mixes at certain degree with common bilayer-forming lipids. Monomeric bacteriorhodopsin and ATP synthase from Micrococcus luteus were co-reconstituted and light-driven ATP synthesis measured. This review reports about almost four decades of research on Thermoplasma membrane and its MPL as well as transfer of this research to Thermoplasma species recently isolated from Indonesian volcanoes. View Full-Text
Keywords: Thermoplasma acidophilum; Thermoplasma volcanium; tetraether lipid; main phospholipid; black lipid membrane; Langmuir-Blodgett monolayer; liposomes; proton permeability; bacteriorhodopsin reconstitution; light-driven ATP synthesis Thermoplasma acidophilum; Thermoplasma volcanium; tetraether lipid; main phospholipid; black lipid membrane; Langmuir-Blodgett monolayer; liposomes; proton permeability; bacteriorhodopsin reconstitution; light-driven ATP synthesis
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Freisleben, H.-J. The Main (Glyco) Phospholipid (MPL) of Thermoplasma acidophilum. Int. J. Mol. Sci. 2019, 20, 5217.

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