Next Article in Journal
Overexpression of WAX INDUCER1/SHINE1 Gene Enhances Wax Accumulation under Osmotic Stress and Oil Synthesis in Brassica napus
Next Article in Special Issue
The Main (Glyco) Phospholipid (MPL) of Thermoplasma acidophilum
Previous Article in Journal
The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer’s Disease and Parkinson’s Disease and Models of Mild Cognitive Impairment
Open AccessReview

In Search for the Membrane Regulators of Archaea

1
Université de Lyon, CNRS, UMR 5240, F-69621 Villeurbanne, France
2
Université de Lyon, INSA de Lyon, UMR 5240, F-69621 Villeurbanne, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4434; https://doi.org/10.3390/ijms20184434
Received: 7 August 2019 / Revised: 4 September 2019 / Accepted: 6 September 2019 / Published: 9 September 2019
(This article belongs to the Special Issue Biochemistry and Biophysics of Archaea Membranes)
Membrane regulators such as sterols and hopanoids play a major role in the physiological and physicochemical adaptation of the different plasmic membranes in Eukarya and Bacteria. They are key to the functionalization and the spatialization of the membrane, and therefore indispensable for the cell cycle. No archaeon has been found to be able to synthesize sterols or hopanoids to date. They also lack homologs of the genes responsible for the synthesis of these membrane regulators. Due to their divergent membrane lipid composition, the question whether archaea require membrane regulators, and if so, what is their nature, remains open. In this review, we review evidence for the existence of membrane regulators in Archaea, and propose tentative location and biological functions. It is likely that no membrane regulator is shared by all archaea, but that they may use different polyterpenes, such as carotenoids, polyprenols, quinones and apolar polyisoprenoids, in response to specific stressors or physiological needs. View Full-Text
Keywords: Archaea; membrane organization; membrane modulators; polyterpenes; carotenoids; polyprenols; quinones; polyisoprenoids; adaptation Archaea; membrane organization; membrane modulators; polyterpenes; carotenoids; polyprenols; quinones; polyisoprenoids; adaptation
Show Figures

Graphical abstract

MDPI and ACS Style

Salvador-Castell, M.; Tourte, M.; Oger, P.M. In Search for the Membrane Regulators of Archaea. Int. J. Mol. Sci. 2019, 20, 4434.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop