Next Article in Journal
Protein and Proteome Atlas for Plants under Stresses: New Highlights and Ways for Integrated Omics in Post-Genomics Era
Next Article in Special Issue
The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications
Previous Article in Journal
The Main (Glyco) Phospholipid (MPL) of Thermoplasma acidophilum
Previous Article in Special Issue
MicroRNA Mediate Visfatin and Resistin Induction of Oxidative Stress in Human Osteoarthritic Synovial Fibroblasts Via NF-κB Pathway
Open AccessReview

Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma

1
Department of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 33302, Taiwan
2
Department of Biomedical Sciences, College of Medicine, Chang-Gung University, Taoyuan 33302, Taiwan
3
Department of General Surgery, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan
4
Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan 33302, Taiwan
5
Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5220; https://doi.org/10.3390/ijms20205220
Received: 26 September 2019 / Revised: 17 October 2019 / Accepted: 18 October 2019 / Published: 21 October 2019
Oxidative stress occurs as a result of imbalance between the generation of reactive oxygen species (ROS) and antioxidant genes in cells, causing damage to lipids, proteins, and DNA. Accumulating damage of cellular components can trigger various diseases, including metabolic syndrome and cancer. Over the past few years, the physiological significance of microRNAs (miRNA) in cancer has been a focus of comprehensive research. In view of the extensive level of miRNA interference in biological processes, the roles of miRNAs in oxidative stress and their relevance in physiological processes have recently become a subject of interest. In-depth research is underway to specifically address the direct or indirect relationships of oxidative stress-induced miRNAs in liver cancer and the potential involvement of the thyroid hormone in these processes. While studies on thyroid hormone in liver cancer are abundantly documented, no conclusive information on the potential relationships among thyroid hormone, specific miRNAs, and oxidative stress in liver cancer is available. In this review, we discuss the effects of thyroid hormone on oxidative stress-related miRNAs that potentially have a positive or negative impact on liver cancer. Additionally, supporting evidence from clinical and animal experiments is provided. View Full-Text
Keywords: oxidative stress; microRNA; thyroid hormone; liver cancer oxidative stress; microRNA; thyroid hormone; liver cancer
Show Figures

Graphical abstract

MDPI and ACS Style

Huang, P.-S.; Wang, C.-S.; Yeh, C.-T.; Lin, K.-H. Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma. Int. J. Mol. Sci. 2019, 20, 5220.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop