Clinical Applications of Natriuretic Peptides in Heart Failure and Atrial Fibrillation
1
Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
2
Department of Cardiology, Ibaraki Prefectural Central Hospital, Kasama 309-1793, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(11), 2824; https://doi.org/10.3390/ijms20112824
Received: 12 April 2019 / Revised: 6 June 2019 / Accepted: 7 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides)
Natriuretic peptides (NPs) have become important diagnostic and prognostic biomarkers in cardiovascular diseases, particularly in heart failure (HF). Diagnosis and management of coronary artery disease and atrial fibrillation (AF) can also be guided by NP levels. When interpreting NP levels, however, the caveat is that age, sex, body mass index, renal dysfunction, and race affect the clearance of NPs, resulting in different cut-off values in clinical practice. In AF, NP levels have been associated with incident AF in the general population, recurrences after catheter ablation, prediction of clinical prognosis, and the risk of stroke. In this article, we first review and summarize the current evidence and the roles of B-type NP and atrial NP in HF and coronary artery disease and then focus on the increasing utility of NPs in the diagnosis and management of and the research into AF.
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Keywords:
natriuretic peptides; heart failure; atrial fibrillation; remodeling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Baba, M.; Yoshida, K.; Ieda, M. Clinical Applications of Natriuretic Peptides in Heart Failure and Atrial Fibrillation. Int. J. Mol. Sci. 2019, 20, 2824. https://doi.org/10.3390/ijms20112824
AMA Style
Baba M, Yoshida K, Ieda M. Clinical Applications of Natriuretic Peptides in Heart Failure and Atrial Fibrillation. International Journal of Molecular Sciences. 2019; 20(11):2824. https://doi.org/10.3390/ijms20112824
Chicago/Turabian StyleBaba, Masako; Yoshida, Kentaro; Ieda, Masaki. 2019. "Clinical Applications of Natriuretic Peptides in Heart Failure and Atrial Fibrillation" Int. J. Mol. Sci. 20, no. 11: 2824. https://doi.org/10.3390/ijms20112824
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