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Exercise and Sirtuins: A Way to Mitochondrial Health in Skeletal Muscle

Department of Medical Sciences, University of Guanajuato, Campus León, 37220 Guanajuato, Mexico
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Int. J. Mol. Sci. 2019, 20(11), 2717; https://doi.org/10.3390/ijms20112717
Received: 30 April 2019 / Revised: 22 May 2019 / Accepted: 23 May 2019 / Published: 3 June 2019
(This article belongs to the Special Issue Sirtuins and Epigenetics in Aging and Diseases)
The sirtuins form a family of evolutionarily conserved nicotinamide adenine dinucleotide (NAD)-dependent deacetylases. Seven sirtuins (SIRT1–SIRT7) have been described in mammals, with specific intracellular localization and biological functions associated with mitochondrial energy homeostasis, antioxidant activity, proliferation and DNA repair. Physical exercise affects the expression of sirtuin in skeletal muscle, regulating changes in mitochondrial biogenesis, oxidative metabolism and the cellular antioxidant system. In this context, sirtuin 1 and sirtuin 3 have been the most studied. This review focuses on the effects of different types of exercise on these sirtuins, the molecular pathways involved and the biological effect that is caused mainly in healthy subjects. The reported findings suggest that an acute load of exercise activates SIRT1, which in turn activates biogenesis and mitochondrial oxidative capacity. Additionally, several sessions of exercise (training) activates SIRT1 and also SIRT3 that, together with the biogenesis and mitochondrial oxidative function, jointly activate ATP production and the mitochondrial antioxidant function. View Full-Text
Keywords: exercise; health; mitochondria; PGC-1α; SIRT1; SIRT3; skeletal muscle; therapeutic target exercise; health; mitochondria; PGC-1α; SIRT1; SIRT3; skeletal muscle; therapeutic target
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MDPI and ACS Style

Vargas-Ortiz, K.; Pérez-Vázquez, V.; Macías-Cervantes, M.H. Exercise and Sirtuins: A Way to Mitochondrial Health in Skeletal Muscle. Int. J. Mol. Sci. 2019, 20, 2717. https://doi.org/10.3390/ijms20112717

AMA Style

Vargas-Ortiz K, Pérez-Vázquez V, Macías-Cervantes MH. Exercise and Sirtuins: A Way to Mitochondrial Health in Skeletal Muscle. International Journal of Molecular Sciences. 2019; 20(11):2717. https://doi.org/10.3390/ijms20112717

Chicago/Turabian Style

Vargas-Ortiz, Katya, Victoriano Pérez-Vázquez, and Maciste H. Macías-Cervantes 2019. "Exercise and Sirtuins: A Way to Mitochondrial Health in Skeletal Muscle" International Journal of Molecular Sciences 20, no. 11: 2717. https://doi.org/10.3390/ijms20112717

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