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Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients

1
Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via L. De Crecchio 7, 80138 Naples, Italy
2
Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
3
Breast Unit and Plastic Surgery, Villa dei Fiori Hospital, 80011 Naples, Italy
4
Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(5), 1153; https://doi.org/10.3390/ijms20051153
Received: 11 January 2019 / Revised: 11 February 2019 / Accepted: 4 March 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Sirtuins and Epigenetics in Aging and Diseases)
The role of sirtuin 6 (SIRT6) in adipose abdominal tissue of pre-diabetic (pre-DM) patients is poorly known. Here, we evaluated SIRT6 expression in visceral abdominal fat of obese pre-diabetic patients and the potential effects of metformin therapy. Results indicated that obese pre-DM subjects showed low SIRT6 protein expression and high expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), peroxisome proliferator-activated receptor gamma (PPAR-γ), and sterol regulatory element-binding transcription factor 1 (SREBP-1). Obese pre-DM patients showed high values of glucose, insulin resistance (HOMA-IR), C reactive protein (CRP), nitrotyrosine, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), and low values of insulin (p < 0.05). Of note, abdominal fat tissue of obese pre-DM patients treated with metformin therapy presented higher SIRT6 expression and lower NF-κB, PPAR-γ, and SREBP-1 expression levels compared to pre-DM control group. Collectively, results show that SIRT6 is involved in the inflammatory pathway of subcutaneous abdominal fat of obese pre-DM patients and its expression responds to metformin therapy. View Full-Text
Keywords: sirtuin 6; obesity; pre-diabetes; NF-κB; PPAR-γ; SREBP-1 sirtuin 6; obesity; pre-diabetes; NF-κB; PPAR-γ; SREBP-1
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MDPI and ACS Style

D’Onofrio, N.; Pieretti, G.; Ciccarelli, F.; Gambardella, A.; Passariello, N.; Rizzo, M.R.; Barbieri, M.; Marfella, R.; Nicoletti, G.; Balestrieri, M.L.; Sardu, C. Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients. Int. J. Mol. Sci. 2019, 20, 1153. https://doi.org/10.3390/ijms20051153

AMA Style

D’Onofrio N, Pieretti G, Ciccarelli F, Gambardella A, Passariello N, Rizzo MR, Barbieri M, Marfella R, Nicoletti G, Balestrieri ML, Sardu C. Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients. International Journal of Molecular Sciences. 2019; 20(5):1153. https://doi.org/10.3390/ijms20051153

Chicago/Turabian Style

D’Onofrio, Nunzia, Gorizio Pieretti, Feliciano Ciccarelli, Antonio Gambardella, Nicola Passariello, Maria R. Rizzo, Michelangela Barbieri, Raffaele Marfella, Gianfranco Nicoletti, Maria L. Balestrieri, and Celestino Sardu. 2019. "Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients" International Journal of Molecular Sciences 20, no. 5: 1153. https://doi.org/10.3390/ijms20051153

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