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Review

Biological Aspects of mTOR in Leukemia

1
Laboratory of Cell Kinetics and Applied Proteomics, Faculty of Medicine and Psychology, Department of Clinic and Molecular Medicine, Sapienza University of Rome, via Rovigo 1, 00161 Rome, Italy
2
Hematology, “Sant’Andrea” University Hospital, Sapienza University of Rome, via di Grottarossa 1035, 00189 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(8), 2396; https://doi.org/10.3390/ijms19082396
Received: 17 July 2018 / Revised: 7 August 2018 / Accepted: 10 August 2018 / Published: 14 August 2018
(This article belongs to the Special Issue mTOR in Human Diseases)
The mammalian target of rapamycin (mTOR) is a central processor of intra- and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival. Strong evidences have indicated that mTOR dysregulation is deeply implicated in leukemogenesis. This has led to growing interest in the development of modulators of its activity for leukemia treatment. This review intends to provide an outline of the principal biological and molecular functions of mTOR. We summarize the current understanding of how mTOR interacts with microRNAs, with components of cell metabolism, and with controllers of apoptotic machinery. Lastly, from a clinical/translational perspective, we recapitulate the therapeutic results in leukemia, obtained by using mTOR inhibitors as single agents and in combination with other compounds. View Full-Text
Keywords: leukemia; cell signaling; metabolism; apoptosis; miRNA; mTOR inhibitors leukemia; cell signaling; metabolism; apoptosis; miRNA; mTOR inhibitors
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MDPI and ACS Style

Mirabilii, S.; Ricciardi, M.R.; Piedimonte, M.; Gianfelici, V.; Bianchi, M.P.; Tafuri, A. Biological Aspects of mTOR in Leukemia. Int. J. Mol. Sci. 2018, 19, 2396. https://doi.org/10.3390/ijms19082396

AMA Style

Mirabilii S, Ricciardi MR, Piedimonte M, Gianfelici V, Bianchi MP, Tafuri A. Biological Aspects of mTOR in Leukemia. International Journal of Molecular Sciences. 2018; 19(8):2396. https://doi.org/10.3390/ijms19082396

Chicago/Turabian Style

Mirabilii, Simone, Maria R. Ricciardi, Monica Piedimonte, Valentina Gianfelici, Maria P. Bianchi, and Agostino Tafuri. 2018. "Biological Aspects of mTOR in Leukemia" International Journal of Molecular Sciences 19, no. 8: 2396. https://doi.org/10.3390/ijms19082396

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