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Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors

Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore 308232, Singapore
Center for Integrative Genomics, University of Lausanne, Génopode, CH-1015 Lausanne, Switzerland
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(8), 2210;
Received: 27 June 2018 / Revised: 18 July 2018 / Accepted: 23 July 2018 / Published: 28 July 2018
(This article belongs to the Special Issue The (Microbiota)–Gut–Brain Axis: Hype or Revolution?)
PDF [2078 KB, uploaded 31 July 2018]


Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota–gut–brain axis. View Full-Text
Keywords: nuclear receptors; microbiota; metabolism; xenobiotics nuclear receptors; microbiota; metabolism; xenobiotics

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Duszka, K.; Wahli, W. Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors. Int. J. Mol. Sci. 2018, 19, 2210.

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