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Article

Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Department of BioNano Technology, Gachon University, 1342 Seongnam-Daero, Sujeong-Gu, Seongnam-Si, Gyeonggi-do 13120, Korea
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School of Chemical and Biomolecular Engineering, Pusan National University, 2 Busandaehak-ro, Geumjeong-Gu, Busan 46241, Korea
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Department of Herbology, College of Korean Medicine, Gachon University, 1342 Seongnam-Daero, Sujeong-Gu, Seongnam-Si, Gyeonggi-do 13120, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1487; https://doi.org/10.3390/ijms19051487
Received: 31 March 2018 / Revised: 7 May 2018 / Accepted: 9 May 2018 / Published: 16 May 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In this study, we investigated the therapeutic potential and medical applications of Sparassis crispa (S. crispa) by conducting a systematic review of the existing literature and performing a meta-analysis. The original efficacy treatment of the mushroom extract is considered primarily and searched in electronic databases. A total of 623 articles were assessed, 33 randomized controlled experiments were included after the manual screening, and some papers, review articles, or editorials that did not contain data were excluded. A comparative standard means difference (SMD) and a funnel plot between control and S. crispa groups were used as parameters to demonstrate the beneficial effects of S. crispa for diabetes and cancer treatment, as well as anti-inflammatory, anti-fungal and antioxidant activities. The meta-analysis was carried out using Review Manager 5.1 software. Although for therapeutic diabetes there was heterogeneity in the subgroup analysis (I2 = 91.9%), the overall results showed statistically significant SMDs in major symptoms that decreased serum insulin levels (SMD = 1.92, 95% CI (1.10, 2.75), I2 = 0%), wound rates (SMD = 3.55 (2.56, 4.54), I2 = 40%) and contributions to an increase in nutrient intake content (SMD = 0.32 (−0.15, 0.78), I2 = 0%). Simultaneously, the study confirmed the utility of S. crispa treatment in terms of not only anti-cancer activity (reduction of tumor activity and survival of cancer cells I2 = 42 and 34%, respectively) but also anti-inflammatory, anti-fungal and antioxidant activities (I2 = 50, 44, and 10%, respectively). Our findings suggest that S. crispa extracts are useful for prevention and treatment of human diseases and might be the best candidates for future medicines. View Full-Text
Keywords: Sparassis crispa; diabetes treatment; cancer therapeutic; anti-inflammatory; anti-fungal; antioxidant activity; meta-analysis Sparassis crispa; diabetes treatment; cancer therapeutic; anti-inflammatory; anti-fungal; antioxidant activity; meta-analysis
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MDPI and ACS Style

Thi Nhu Ngoc, L.; Oh, Y.-K.; Lee, Y.-J.; Lee, Y.-C. Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Int. J. Mol. Sci. 2018, 19, 1487. https://doi.org/10.3390/ijms19051487

AMA Style

Thi Nhu Ngoc L, Oh Y-K, Lee Y-J, Lee Y-C. Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Molecular Sciences. 2018; 19(5):1487. https://doi.org/10.3390/ijms19051487

Chicago/Turabian Style

Thi Nhu Ngoc, Le, You-Kwan Oh, Young-Jong Lee, and Young-Chul Lee. 2018. "Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" International Journal of Molecular Sciences 19, no. 5: 1487. https://doi.org/10.3390/ijms19051487

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