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Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer

Research Center, Scripps Korea Antibody Institute, Chuncheon 200-701, Korea
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Int. J. Mol. Sci. 2018, 19(4), 1057; https://doi.org/10.3390/ijms19041057
Received: 19 March 2018 / Revised: 30 March 2018 / Accepted: 31 March 2018 / Published: 2 April 2018
(This article belongs to the Special Issue Tumor Necrosis Factor (TNF))
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Abstract

Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that triggers the expression of inflammatory molecules, including other cytokines and cell adhesion molecules. TNFα induces the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 (VCAM-1). VCAM-1 was originally identified as a cell adhesion molecule that helps regulate inflammation-associated vascular adhesion and the transendothelial migration of leukocytes, such as macrophages and T cells. Recent evidence suggests that VCAM-1 is closely associated with the progression of various immunological disorders, including rheumatoid arthritis, asthma, transplant rejection, and cancer. This review covers the role and relevance of VCAM-1 in inflammation, and also highlights the emerging potential of VCAM-1 as a novel therapeutic target in immunological disorders and cancer. View Full-Text
Keywords: antibody; cancer; inflammation; immunological disorder; therapeutic target; tumor necrosis factor α; vascular cell adhesion molecule-1 antibody; cancer; inflammation; immunological disorder; therapeutic target; tumor necrosis factor α; vascular cell adhesion molecule-1
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kong, D.-H.; Kim, Y.K.; Kim, M.R.; Jang, J.H.; Lee, S. Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer. Int. J. Mol. Sci. 2018, 19, 1057.

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