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Int. J. Mol. Sci. 2018, 19(12), 3950; https://doi.org/10.3390/ijms19123950

Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy

1
Research Unit, REDISSEC, Hospital Costa del Sol, Autovía A-7, km 187, 29603 Marbella, Málaga, Spain
2
Oncology Department, Hospital Costa del Sol, Autovía A-7, km 187, 29603 Marbella, Málaga, Spain
3
Research Unit, REDISSEC, Hospital Costa del Sol, Universidad de Málaga, Autovía A-7 km 187, 29603 Marbella, Málaga, Spain
*
Author to whom correspondence should be addressed.
Received: 29 October 2018 / Revised: 4 December 2018 / Accepted: 6 December 2018 / Published: 8 December 2018
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Abstract

Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy. View Full-Text
Keywords: Bcl-2; resistance; apoptosis; inhibition; cancer; chemotherapy; immunotherapy Bcl-2; resistance; apoptosis; inhibition; cancer; chemotherapy; immunotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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García-Aranda, M.; Pérez-Ruiz, E.; Redondo, M. Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy. Int. J. Mol. Sci. 2018, 19, 3950.

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