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Int. J. Mol. Sci. 2018, 19(12), 3770;

The Ambivalent Function of YAP in Apoptosis and Cancer

Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee 69a, 18059 Rostock, Germany
Author to whom correspondence should be addressed.
Received: 12 October 2018 / Revised: 16 November 2018 / Accepted: 23 November 2018 / Published: 27 November 2018
PDF [972 KB, uploaded 29 November 2018]


Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is also an essential contributor of p73-mediated apoptosis. This questions the concept that yes-associated protein is always a good target for developing novel anti-cancer drugs. Thus, the aim of this review was to evaluate the clinical relevance of yes-associated protein for cancer pathophysiology. This review also summarized the molecules, processes and drugs, which regulate Hippo-YAP signaling and discusses their effect on apoptosis. In addition, issues are defined, which should be addressed in the future in order to provide a solid basis for targeting the Hippo-YAP signaling pathway in clinical trials. View Full-Text
Keywords: Hippo; YAP; signaling pathway; cell death; autophagy; p73; cancer; therapy Hippo; YAP; signaling pathway; cell death; autophagy; p73; cancer; therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, X.; Abdelrahman, A.; Vollmar, B.; Zechner, D. The Ambivalent Function of YAP in Apoptosis and Cancer. Int. J. Mol. Sci. 2018, 19, 3770.

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