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Review

Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

1
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy
2
Scientific Secretary-Council for Nutritional and Environmental Medicine (CONEM), 8610 Mo i Rana, Norway
3
Council for Nutritional and Environmental Medicine (CONEM), 8610 Mo i Rana, Norway
4
Department of Pharmacognosy and Botany, DanyloHalytskyLviv National Medical University, 79007 Lviv, Ukraine
5
AOUI Verona, University Hospital, Section of Immunology, 37134 Verona, Italy
6
Department of Chemistry of Natural Compounds, National University of Pharmacy, 61168 Kharkiv, Ukraine
7
Department of Pharmacognosy, National University of Pharmacy, 61168 Kharkiv, Ukraine
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(11), 3568; https://doi.org/10.3390/ijms19113568
Received: 26 October 2018 / Revised: 6 November 2018 / Accepted: 9 November 2018 / Published: 12 November 2018
(This article belongs to the Special Issue The Effect of Dietary Factors on Cancer)
The role of phytochemicals as potential prodrugs or therapeutic substances against tumors has come in the spotlight in the very recent years, thanks to the huge mass of encouraging and promising results of the in vitro activity of many phenolic compounds from plant raw extracts against many cancer cell lines. Little but important evidence can be retrieved from the clinical and nutritional scientific literature, where flavonoids are investigated as major pro-apoptotic and anti-metastatic compounds. However, the actual role of these compounds in cancer is still far to be fully elucidated. Many of these phytochemicals act in a pleiotropic and poorly specific manner, but, more importantly, they are able to tune the reactive oxygen species (ROS) signaling to activate a survival or a pro-autophagic and pro-apoptosis mechanism, depending on the oxidative stress-responsive endowment of the targeted cell. This review will try to focus on this issue. View Full-Text
Keywords: phytochemicals; flavonoids; cancer; mitochondria; apoptosis phytochemicals; flavonoids; cancer; mitochondria; apoptosis
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MDPI and ACS Style

Chirumbolo, S.; Bjørklund, G.; Lysiuk, R.; Vella, A.; Lenchyk, L.; Upyr, T. Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways. Int. J. Mol. Sci. 2018, 19, 3568. https://doi.org/10.3390/ijms19113568

AMA Style

Chirumbolo S, Bjørklund G, Lysiuk R, Vella A, Lenchyk L, Upyr T. Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways. International Journal of Molecular Sciences. 2018; 19(11):3568. https://doi.org/10.3390/ijms19113568

Chicago/Turabian Style

Chirumbolo, Salvatore, Geir Bjørklund, Roman Lysiuk, Antonio Vella, Larysa Lenchyk, and Taras Upyr. 2018. "Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways" International Journal of Molecular Sciences 19, no. 11: 3568. https://doi.org/10.3390/ijms19113568

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