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Werner Syndrome Protein and DNA Replication

Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
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Int. J. Mol. Sci. 2018, 19(11), 3442; https://doi.org/10.3390/ijms19113442
Received: 17 September 2018 / Revised: 22 October 2018 / Accepted: 25 October 2018 / Published: 2 November 2018
(This article belongs to the Special Issue DNA Replication Stress)
Werner Syndrome (WS) is an autosomal recessive disorder characterized by the premature development of aging features. Individuals with WS also have a greater predisposition to rare cancers that are mesenchymal in origin. Werner Syndrome Protein (WRN), the protein mutated in WS, is unique among RecQ family proteins in that it possesses exonuclease and 3′ to 5′ helicase activities. WRN forms dynamic sub-complexes with different factors involved in DNA replication, recombination and repair. WRN binding partners either facilitate its DNA metabolic activities or utilize it to execute their specific functions. Furthermore, WRN is phosphorylated by multiple kinases, including Ataxia telangiectasia mutated, Ataxia telangiectasia and Rad3 related, c-Abl, Cyclin-dependent kinase 1 and DNA-dependent protein kinase catalytic subunit, in response to genotoxic stress. These post-translational modifications are critical for WRN to function properly in DNA repair, replication and recombination. Accumulating evidence suggests that WRN plays a crucial role in one or more genome stability maintenance pathways, through which it suppresses cancer and premature aging. Among its many functions, WRN helps in replication fork progression, facilitates the repair of stalled replication forks and DNA double-strand breaks associated with replication forks, and blocks nuclease-mediated excessive processing of replication forks. In this review, we specifically focus on human WRN’s contribution to replication fork processing for maintaining genome stability and suppressing premature aging. Understanding WRN’s molecular role in timely and faithful DNA replication will further advance our understanding of the pathophysiology of WS. View Full-Text
Keywords: cancer; DNA double-strand repair; premature aging; post-translational modification; protein stability; replication stress; Werner Syndrome; Werner Syndrome Protein cancer; DNA double-strand repair; premature aging; post-translational modification; protein stability; replication stress; Werner Syndrome; Werner Syndrome Protein
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MDPI and ACS Style

Mukherjee, S.; Sinha, D.; Bhattacharya, S.; Srinivasan, K.; Abdisalaam, S.; Asaithamby, A. Werner Syndrome Protein and DNA Replication. Int. J. Mol. Sci. 2018, 19, 3442.

AMA Style

Mukherjee S, Sinha D, Bhattacharya S, Srinivasan K, Abdisalaam S, Asaithamby A. Werner Syndrome Protein and DNA Replication. International Journal of Molecular Sciences. 2018; 19(11):3442.

Chicago/Turabian Style

Mukherjee, Shibani; Sinha, Debapriya; Bhattacharya, Souparno; Srinivasan, Kalayarasan; Abdisalaam, Salim; Asaithamby, Aroumougame. 2018. "Werner Syndrome Protein and DNA Replication" Int. J. Mol. Sci. 19, no. 11: 3442.

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