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Open AccessArticle

The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
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Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Int. J. Mol. Sci. 2017, 18(3), 602; https://doi.org/10.3390/ijms18030602
Received: 8 January 2017 / Revised: 14 February 2017 / Accepted: 4 March 2017 / Published: 10 March 2017
(This article belongs to the Section Biochemistry)
Asthma is a chronic inflammatory disorder of the airway and is characterized by airway remodeling, hyperresponsiveness, and shortness of breath. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicines (TCM), has been demonstrated to have good therapeutic effects on experimental allergic asthma. However, its anti-asthma mechanism remains currently unknown. In the present work, metabolomics studies of biochemical changes in the lung tissue and plasma of ovalbumin (OVA)-induced allergic asthma mice with mKG treatment were performed using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Partial least squares–discriminate analysis (PLS−DA) indicated that the metabolic perturbation induced by OVA was reduced after mKG treatment. A total of twenty-four metabolites involved in seven metabolic pathways were identified as potential biomarkers in the development of allergic asthma. Among them, myristic acid (L3 or P2), sphinganine (L6 or P4), and lysoPC(15:0) (L12 or P16) were detected both in lung tissue and plasma. Additionally, l-acetylcarnitine (L1), thromboxane B2 (L2), 10-HDoHE (L10), and 5-HETE (L11) were first reported to be potential biomarkers associated with allergic asthma. The treatment of mKG mediated all of those potential biomarkers except lysoPC(15:0) (P16). The anti-asthma mechanism of mKG can be achieved through the comprehensive regulation of multiple perturbed biomarkers and metabolic pathways. View Full-Text
Keywords: allergic asthma; mKG; Sophora flavescens; Glycyrrhiza uralensis; Angelica oil; metabolomics; biomarkers; UPLC-Q-TOF/MS allergic asthma; mKG; Sophora flavescens; Glycyrrhiza uralensis; Angelica oil; metabolomics; biomarkers; UPLC-Q-TOF/MS
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MDPI and ACS Style

Yu, M.; Jia, H.-M.; Cui, F.-X.; Yang, Y.; Zhao, Y.; Yang, M.-H.; Zou, Z.-M. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. Int. J. Mol. Sci. 2017, 18, 602. https://doi.org/10.3390/ijms18030602

AMA Style

Yu M, Jia H-M, Cui F-X, Yang Y, Zhao Y, Yang M-H, Zou Z-M. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. International Journal of Molecular Sciences. 2017; 18(3):602. https://doi.org/10.3390/ijms18030602

Chicago/Turabian Style

Yu, Meng; Jia, Hong-Mei; Cui, Feng-Xia; Yang, Yong; Zhao, Yang; Yang, Mao-Hua; Zou, Zhong-Mei. 2017. "The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations" Int. J. Mol. Sci. 18, no. 3: 602. https://doi.org/10.3390/ijms18030602

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