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Int. J. Mol. Sci. 2016, 17(9), 1533;

Apoptosis in Porcine Pluripotent Cells: From ICM to iPSCs

Institute for Stem Cell & Regenerative Medicine (ISCRM), Chungbuk National University, Cheongju 28644, Chungbuk, Korea
Laboratory of Veterinary Embryology and Biotechnology(VETEMBIO), Veterinary Medical Center and Collage of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Korea
Author to whom correspondence should be addressed.
Academic Editor: Anthony Lemarié
Received: 4 August 2016 / Revised: 4 August 2016 / Accepted: 8 September 2016 / Published: 12 September 2016
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
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Pigs have great potential to provide preclinical models for human disease in translational research because of their similarities with humans. In this regard, porcine pluripotent cells, which are able to differentiate into cells of all three primary germ layers, might be a suitable animal model for further development of regenerative medicine. Here, we describe the current state of knowledge on apoptosis in pluripotent cells including inner cell mass (ICM), epiblast, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). Information is focused on the apoptotic phenomenon in pluripotency, maintenance, and differentiation of pluripotent stem cells and reprogramming of somatic cells in pigs. Additionally, this review examines the multiple roles of apoptosis and summarizes recent progress in porcine pluripotent cells. View Full-Text
Keywords: apoptosis; embryo; embryonic stem cells; induced pluripotent stem cells; pigs apoptosis; embryo; embryonic stem cells; induced pluripotent stem cells; pigs

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kim, E.; Hyun, S.-H. Apoptosis in Porcine Pluripotent Cells: From ICM to iPSCs. Int. J. Mol. Sci. 2016, 17, 1533.

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