Next Article in Journal
TNFSF4 Gene Variations Are Related to Early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto’s Thyroiditis
Next Article in Special Issue
Apoptosis in Porcine Pluripotent Cells: From ICM to iPSCs
Previous Article in Journal
Involvement of Three Esterase Genes from Panonychus citri (McGregor) in Fenpropathrin Resistance
Previous Article in Special Issue
Apoptotic Pathways Linked to Endocrine System as Potential Therapeutic Targets for Benign Prostatic Hyperplasia
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(8), 1365;

Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao Sung, Kaohsiung 833, Taiwan
Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Linkou, Taoyuan 333, Taiwan
Authors to whom correspondence should be addressed.
Academic Editor: Anthony Lemarié
Received: 6 June 2016 / Revised: 1 August 2016 / Accepted: 15 August 2016 / Published: 20 August 2016
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
Full-Text   |   PDF [6107 KB, uploaded 20 August 2016]   |  


Bile duct ligation (BDL)-treated rats display cholestasis and liver damages. The potential protective activity of melatonin in young BDL rats in terms of apoptosis, mitochondrial function, and endoplasmic reticulum (ER) homeostasis has not yet been evaluated. Three groups of young male Sprague-Dawley rats were used: one group received laparotomy (Sham), a second group received BDL for two weeks (BDL), and a third group received BDL and intraperitoneal melatonin (100 mg/day) for two weeks (BDL + M). BDL group rats showed liver apoptosis, increased pro-inflamamtory mediators, caspases alterations, anti-apoptotic factors changes, and dysfunction of ER homeostasis. Melatonin effectively reversed apoptosis, mainly through intrinsic pathway and reversed ER stress. In addition, in vitro study showed melatonin exerted its effect mainly through the melatonin 2 receptor (MT2) in HepG2 cells. In conclusion, BDL in young rats caused liver apoptosis. Melatonin rescued the apoptotic changes via the intrinsic pathway, and possibly through the MT2 receptor. Melatonin also reversed ER stress induced by BDL. View Full-Text
Keywords: bile duct ligation; melatonin; apoptosis; endoplasmic reticulum; mitochondria bile duct ligation; melatonin; apoptosis; endoplasmic reticulum; mitochondria

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Sheen, J.-M.; Chen, Y.-C.; Hsu, M.-H.; Tain, Y.-L.; Huang, Y.-H.; Tiao, M.-M.; Li, S.-W.; Huang, L.-T. Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats. Int. J. Mol. Sci. 2016, 17, 1365.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top