Next Article in Journal
Binding and Fusion of Extracellular Vesicles to the Plasma Membrane of Their Cell Targets
Next Article in Special Issue
Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells
Previous Article in Journal
Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model
Previous Article in Special Issue
Evaluation of Pulmonary Toxicity of Zinc Oxide Nanoparticles Following Inhalation and Intratracheal Instillation
Open AccessReview

Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles

1
Research Institute for Fundamental and Clinical Uronephrology, Saratov State Medical University, n.a. V.I. Razumovsky, 410012 Saratov, Russia
2
Research-Education Institute of Optics and Biophotonics, Saratov National Research State University, 410012 Saratov, Russia
3
Institute of Precision Mechanics and Control, RAS, 410028 Saratov, Russia
4
Artphotonics GmbH, 12489 Berlin, Germany
5
Optoelectronics and Measurement Techniques Laboratory, University of Oulu, 90014 Oulu, Finland
6
Institute of Analytical and Bioanalytical Chemistry, Ulm University, 89081 Ulm, Germany
7
Department of Biology, Saratov National Research State University, 410012 Saratov, Russia
8
Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 410049 Saratov, Russia
9
Department of Nano- and Biomedical Technologies, Saratov National Research State University, 410012 Saratov, Russia
10
Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, 634050 Tomsk, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Vladimir Sivakov
Int. J. Mol. Sci. 2016, 17(8), 1295; https://doi.org/10.3390/ijms17081295
Received: 13 June 2016 / Revised: 22 July 2016 / Accepted: 29 July 2016 / Published: 9 August 2016
(This article belongs to the Special Issue Inorganic Nanostructures in Biological Systems)
Gold nanoparticles (AuNPs) of different size and shape are widely used as photosensitizers for cancer diagnostics and plasmonic photothermal (PPT)/photodynamic (PDT) therapy, as nanocarriers for drug delivery and laser-mediated pathogen killing, even the underlying mechanisms of treatment effects remain poorly understood. There is a need in analyzing and improving the ways to increase accumulation of AuNP in tumors and other crucial steps in interaction of AuNPs with laser light and tissues. In this review, we summarize our recent theoretical, experimental, and pre-clinical results on light activated interaction of AuNPs with tissues and cells. Specifically, we discuss a combined PPT/PDT treatment of tumors and killing of pathogen bacteria with gold-based nanocomposites and atomic clusters, cell optoporation, and theoretical simulations of nanoparticle-mediated laser heating of tissues and cells. View Full-Text
Keywords: Au nanoparticles; nanorods; nanostars; silica; nanocomposites; photothermal therapy (PPT); photodynamic therapy (PDT); pathogens; tumors; cell optoporation Au nanoparticles; nanorods; nanostars; silica; nanocomposites; photothermal therapy (PPT); photodynamic therapy (PDT); pathogens; tumors; cell optoporation
Show Figures

Graphical abstract

MDPI and ACS Style

Bucharskaya, A.; Maslyakova, G.; Terentyuk, G.; Yakunin, A.; Avetisyan, Y.; Bibikova, O.; Tuchina, E.; Khlebtsov, B.; Khlebtsov, N.; Tuchin, V. Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles. Int. J. Mol. Sci. 2016, 17, 1295. https://doi.org/10.3390/ijms17081295

AMA Style

Bucharskaya A, Maslyakova G, Terentyuk G, Yakunin A, Avetisyan Y, Bibikova O, Tuchina E, Khlebtsov B, Khlebtsov N, Tuchin V. Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles. International Journal of Molecular Sciences. 2016; 17(8):1295. https://doi.org/10.3390/ijms17081295

Chicago/Turabian Style

Bucharskaya, Alla; Maslyakova, Galina; Terentyuk, Georgy; Yakunin, Alexander; Avetisyan, Yuri; Bibikova, Olga; Tuchina, Elena; Khlebtsov, Boris; Khlebtsov, Nikolai; Tuchin, Valery. 2016. "Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles" Int. J. Mol. Sci. 17, no. 8: 1295. https://doi.org/10.3390/ijms17081295

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop