Next Article in Journal
Transcriptomic Insights into the Response of Placenta and Decidua Basalis to the CpG Oligodeoxynucleotide Stimulation in Non-Obese Diabetic Mice and Wild-Type Controls
Previous Article in Journal
Environmental Microbial Community Proteomics: Status, Challenges and Perspectives
Review

Epigenetic Modifications of Major Depressive Disorder

1
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile
2
Millennium Institute for Research in Depression and Personality (MIDAP), Universidad de La Frontera, Temuco 4811230, Chile
*
Author to whom correspondence should be addressed.
Academic Editor: Stephen A. Bustin
Int. J. Mol. Sci. 2016, 17(8), 1279; https://doi.org/10.3390/ijms17081279
Received: 20 June 2016 / Revised: 24 July 2016 / Accepted: 29 July 2016 / Published: 5 August 2016
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evidence suggesting that environmental factors play an important role in MDD pathophysiology. Alterations in epigenetics mechanism, such as DNA methylation, histone modification and microRNA expression could favor MDD advance in response to stressful experiences and environmental factors. The aim of this review is to describe genetic alterations, and particularly altered epigenetic mechanisms, that could be determinants for MDD progress, and how these alterations may arise as useful screening, diagnosis and treatment monitoring biomarkers of depressive disorders. View Full-Text
Keywords: major depressive disorder; depression; epigenetic modifications; methylation; histone modification; miRNAs; biomarkers major depressive disorder; depression; epigenetic modifications; methylation; histone modification; miRNAs; biomarkers
Show Figures

Graphical abstract

MDPI and ACS Style

Saavedra, K.; Molina-Márquez, A.M.; Saavedra, N.; Zambrano, T.; Salazar, L.A. Epigenetic Modifications of Major Depressive Disorder. Int. J. Mol. Sci. 2016, 17, 1279. https://doi.org/10.3390/ijms17081279

AMA Style

Saavedra K, Molina-Márquez AM, Saavedra N, Zambrano T, Salazar LA. Epigenetic Modifications of Major Depressive Disorder. International Journal of Molecular Sciences. 2016; 17(8):1279. https://doi.org/10.3390/ijms17081279

Chicago/Turabian Style

Saavedra, Kathleen, Ana M. Molina-Márquez, Nicolás Saavedra, Tomás Zambrano, and Luis A. Salazar. 2016. "Epigenetic Modifications of Major Depressive Disorder" International Journal of Molecular Sciences 17, no. 8: 1279. https://doi.org/10.3390/ijms17081279

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop