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Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome

Physiology Department, Morehouse School of Medicine, Atlanta, GA 30310, USA
Mathematics Department, Clark Atlanta University, Atlanta, GA 30314, USA
Physics Department, Clark Atlanta University, Atlanta, GA 30314, USA
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Int. J. Mol. Sci. 2016, 17(6), 830;
Received: 31 March 2016 / Revised: 12 May 2016 / Accepted: 19 May 2016 / Published: 8 June 2016
(This article belongs to the Special Issue MicroRNA Regulation)
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RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression. View Full-Text
Keywords: miRNA; transcriptome; exosome miRNA; transcriptome; exosome

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Seffens, W.; Abebe, F.; Evans, C.; Wang, X.-Q. Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome. Int. J. Mol. Sci. 2016, 17, 830.

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