From End to End: tRNA Editing at 5'- and 3'-Terminal Positions
AbstractDuring maturation, tRNA molecules undergo a series of individual processing steps, ranging from exo- and endonucleolytic trimming reactions at their 5'- and 3'-ends, specific base modifications and intron removal to the addition of the conserved 3'-terminal CCA sequence. Especially in mitochondria, this plethora of processing steps is completed by various editing events, where base identities at internal positions are changed and/or nucleotides at 5'- and 3'-ends are replaced or incorporated. In this review, we will focus predominantly on the latter reactions, where a growing number of cases indicate that these editing events represent a rather frequent and widespread phenomenon. While the mechanistic basis for 5'- and 3'-end editing differs dramatically, both reactions represent an absolute requirement for generating a functional tRNA. Current in vivo and in vitro model systems support a scenario in which these highly specific maturation reactions might have evolved out of ancient promiscuous RNA polymerization or quality control systems. View Full-Text
Share & Cite This Article
Betat, H.; Long, Y.; Jackman, J.E.; Mörl, M. From End to End: tRNA Editing at 5'- and 3'-Terminal Positions. Int. J. Mol. Sci. 2014, 15, 23975-23998.
Betat H, Long Y, Jackman JE, Mörl M. From End to End: tRNA Editing at 5'- and 3'-Terminal Positions. International Journal of Molecular Sciences. 2014; 15(12):23975-23998.Chicago/Turabian Style
Betat, Heike; Long, Yicheng; Jackman, Jane E.; Mörl, Mario. 2014. "From End to End: tRNA Editing at 5'- and 3'-Terminal Positions." Int. J. Mol. Sci. 15, no. 12: 23975-23998.