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Int. J. Mol. Sci. 2014, 15(12), 23975-23998;

From End to End: tRNA Editing at 5'- and 3'-Terminal Positions

Institute for Biochemistry, University of Leipzig, Brüderstraße 34, 04103 Leipzig, Germany
Department of Chemistry and Biochemistry, Center for RNA Biology and Ohio State Biochemistry Program, the Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Received: 16 November 2014 / Revised: 10 December 2014 / Accepted: 16 December 2014 / Published: 22 December 2014
(This article belongs to the Special Issue Functions of Transfer RNAs)
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During maturation, tRNA molecules undergo a series of individual processing steps, ranging from exo- and endonucleolytic trimming reactions at their 5'- and 3'-ends, specific base modifications and intron removal to the addition of the conserved 3'-terminal CCA sequence. Especially in mitochondria, this plethora of processing steps is completed by various editing events, where base identities at internal positions are changed and/or nucleotides at 5'- and 3'-ends are replaced or incorporated. In this review, we will focus predominantly on the latter reactions, where a growing number of cases indicate that these editing events represent a rather frequent and widespread phenomenon. While the mechanistic basis for 5'- and 3'-end editing differs dramatically, both reactions represent an absolute requirement for generating a functional tRNA. Current in vivo and in vitro model systems support a scenario in which these highly specific maturation reactions might have evolved out of ancient promiscuous RNA polymerization or quality control systems. View Full-Text
Keywords: tRNA; editing; tRNA processing; tRNA maturation tRNA; editing; tRNA processing; tRNA maturation

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Betat, H.; Long, Y.; Jackman, J.E.; Mörl, M. From End to End: tRNA Editing at 5'- and 3'-Terminal Positions. Int. J. Mol. Sci. 2014, 15, 23975-23998.

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