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Int. J. Mol. Sci. 2014, 15(12), 23725-23748;

Regulation of Angiogenesis by Aminoacyl-tRNA Synthetases

Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT 05405, USA
Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
Author to whom correspondence should be addressed.
Received: 17 November 2014 / Revised: 11 December 2014 / Accepted: 12 December 2014 / Published: 19 December 2014
(This article belongs to the Special Issue Functions of Transfer RNAs)
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In addition to their canonical roles in translation the aminoacyl-tRNA synthetases (ARSs) have developed secondary functions over the course of evolution. Many of these activities are associated with cellular survival and nutritional stress responses essential for homeostatic processes in higher eukaryotes. In particular, six ARSs and one associated factor have documented functions in angiogenesis. However, despite their connection to this process, the ARSs are mechanistically distinct and exhibit a range of positive or negative effects on aspects of endothelial cell migration, proliferation, and survival. This variability is achieved through the appearance of appended domains and interplay with inflammatory pathways not found in prokaryotic systems. Complete knowledge of the non-canonical functions of ARSs is necessary to understand the mechanisms underlying the physiological regulation of angiogenesis. View Full-Text
Keywords: angiogenesis; aminoacyl-tRNA synthetase; endothelial cells; non-canonical functions angiogenesis; aminoacyl-tRNA synthetase; endothelial cells; non-canonical functions

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Mirando, A.C.; Francklyn, C.S.; Lounsbury, K.M. Regulation of Angiogenesis by Aminoacyl-tRNA Synthetases. Int. J. Mol. Sci. 2014, 15, 23725-23748.

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