A Case of Stage III c Ovarian Clear Cell Carcinoma:  The Role for Predictive Biomarkers and Targeted Therapies

doi:10.3390/ijms14036067

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Int. J. Mol. Sci. 2013, 14(3), 6067-6073; doi:10.3390/ijms14036067

Case Report

A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies

Munmun Rahman¹

, Kentaro Nakayama^1,* , Tomoka Ishibashi¹

, Masako Ishikawa¹

, Mohammed Tanjimur Rahman¹

, Hiroshi Katagiri¹

, Atsuko Katagiri¹

, Kouji Iida¹

, Yoshihiro Kikuchi²

and Kohji Miyazaki¹

+ Authors' affiliations

Received: 17 February 2013 / Revised: 11 March 2013 / Accepted: 12 March 2013 / Published: 15 March 2013

(This article belongs to the Special Issue Genes and Pathways in the Pathogenesis of Ovarian Cancer)

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Abstract: Ovarian cancer treatment presently does not reflect molecular differences in histologic subtype. Ovarian clear cell carcinoma (OCCC) exhibits several differences in terms of molecular pathogenesis and tumor behavior from the more common, chemosensitive, serous carcinomas, which makes OCCC a candidate for targeted therapies. A 53-year-old Japanese woman was diagnosed with stage IIIc ovarian clear cell adenocarcinoma with marked chemoresistance to conventional regimens. She demonstrated a partial response to a multikinase inhibitor. The tumor was resistant to PI3K/mTOR pathway inhibitors despite harboring a PIK3CA mutation. The present case suggests a role for targeted therapies in the treatment of OCCC and a need for the identification of biomarkers that will predict response to targeted therapies.

Keywords: ovarian clear cell carcinoma; biomarkers; PIK3CA; mTOR inhibitor

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rahman, M.; Nakayama, K.; Ishibashi, T.; Ishikawa, M.; Rahman, M.T.; Katagiri, H.; Katagiri, A.; Iida, K.; Kikuchi, Y.; Miyazaki, K. A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies. Int. J. Mol. Sci. 2013, 14, 6067-6073.

AMA Style

Rahman M, Nakayama K, Ishibashi T, Ishikawa M, Rahman MT, Katagiri H, Katagiri A, Iida K, Kikuchi Y, Miyazaki K. A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies. International Journal of Molecular Sciences. 2013; 14(3):6067-6073.

Chicago/Turabian Style

Rahman, Munmun; Nakayama, Kentaro; Ishibashi, Tomoka; Ishikawa, Masako; Rahman, Mohammed T.; Katagiri, Hiroshi; Katagiri, Atsuko; Iida, Kouji; Kikuchi, Yoshihiro; Miyazaki, Kohji. 2013. "A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies." Int. J. Mol. Sci. 14, no. 3: 6067-6073.

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