Natural Tyrosinase Inhibitors from Lycopodium japonicum
Abstract
1. Introduction
2. Results
2.1. Structure Elucidation of the Isolates
2.2. Tyrosinase Inhibitory Bioassays
2.3. Molecular Docking Studies
3. Materials and Methods
3.1. General Experimental Procedures
3.2. Plant Material
3.3. Extraction and Isolation
3.4. Characteristic 1H and 13C NMR Spectral Data of Isolates
3.5. In Vitro Tyrosinase Inhibitory Bioassay
3.6. Molecular Docking Experiments
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Compounds | Names | References |
---|---|---|
1 | 16-oxo-3α-hydroxyserrat-14-en-21β-ol | [16] |
2 | 21-epi-serratenediol | [24] |
3 | 3β-hydroxy-14-serraten-21-one | [25] |
4 | serratenediol | [24,26] |
5 | methyl lycernuate A | [27,28] |
6 | α-onocerin | [29] |
7 | 26-nor-8-oxo-α-onocerin | [30] |
8 | β-stiosterol | [23] |
9 | trans-ethyl ferulate | [31] |
10 | cis-ethyl ferulate | [31,32] |
11 | ethyl 4-hydroxy-3-methoxybenzoate | [33] |
12 | 2,4-di-tert-butylphenol | [34] |
13 | ginkwanghol A | [35] |
14 | 5-ethoxymethylfurfural | [36] |
15 | 5-hydroxymethyl furfural | [37] |
Compounds | IC50 (mM) |
---|---|
4 | 2.16 ± 0.03 |
12 | 3.28 ± 0.03 |
13 | 1.46 ± 0.03 |
14 | 5.92 ± 0.06 |
15 | 6.82 ± 0.09 |
Kojic acid 1 | 0.17 ± 0.01 |
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Ge, Z.-Y.; Wang, Y.-Q.; Yang, Q.-B.; Yan, X.-Y.; Wu, L.; Zhang, M.; Liang, L.-F. Natural Tyrosinase Inhibitors from Lycopodium japonicum. Molecules 2025, 30, 4024. https://doi.org/10.3390/molecules30194024
Ge Z-Y, Wang Y-Q, Yang Q-B, Yan X-Y, Wu L, Zhang M, Liang L-F. Natural Tyrosinase Inhibitors from Lycopodium japonicum. Molecules. 2025; 30(19):4024. https://doi.org/10.3390/molecules30194024
Chicago/Turabian StyleGe, Zeng-Yue, Ya-Qing Wang, Qi-Bin Yang, Xian-Yun Yan, Lei Wu, Min Zhang, and Lin-Fu Liang. 2025. "Natural Tyrosinase Inhibitors from Lycopodium japonicum" Molecules 30, no. 19: 4024. https://doi.org/10.3390/molecules30194024
APA StyleGe, Z.-Y., Wang, Y.-Q., Yang, Q.-B., Yan, X.-Y., Wu, L., Zhang, M., & Liang, L.-F. (2025). Natural Tyrosinase Inhibitors from Lycopodium japonicum. Molecules, 30(19), 4024. https://doi.org/10.3390/molecules30194024