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Molecules
Volume 28
Issue 2
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Article
Peer-Review Record

Napyradiomycin A4 and Its Relate Compounds, a New Anti-PRV Agent and Their Antibacterial Activities, from Streptomyces kebangsaanensis WS-68302

Molecules 2023, 28(2), 640; https://doi.org/10.3390/molecules28020640
by Yani Zhang †, Wei Fang †, Kaimei Wang, Zhigang Zhang, Zhaoyuan Wu, Liqiao Shi, Fang Liu, Zhongyi Wan * and Manli Liu *
Reviewer 1: Anonymous
Reviewer 2:
Apollinaire Tsopmo
Molecules 2023, 28(2), 640; https://doi.org/10.3390/molecules28020640
Submission received: 14 November 2022 / Revised: 28 December 2022 / Accepted: 31 December 2022 / Published: 8 January 2023
(This article belongs to the Special Issue Extraction, Assessment and Function Mechanism of Bioactivities from Natural Products and Microorganism Metabolites)

Round 1

Reviewer 1 Report

Please see the attachment

Comments for author File: Comments.pdf

Author Response

Dear reviewer#1:

   Thank you very much for the comments, we considered and response each of comments point by point. Our response to the comments is listed in the response document, please see the attachment.

Best regards,

Yani Zhang

Author Response File: Author Response.pdf

Reviewer 2 Report

An interesting paper

The structural characterisation by NMR is well done.

The discussion of the mechanism of the compounds is weak and should expended

 

L15. Full name of PRV

L15-20. Provide errors on IC50 values and other data

L26. “the porcine disease infected by…” This is an incorrect sentence

L35-36. Grammar issue. May be revised to … bacteria such as Streptococcus suis …

L36-37. “S. suis, an important zoonotic”. Missing a verb

L41. …have three main…

L41. Delete including as all forms are listed

L44. It’s not the antibiotics that are resistant.

L47. semi-naphthoquinone nucleus and isoprene unit or a monoterpenoid are included as classes of meroterpenoids, but they are not

L53. mycetes to be demonstrated: incorrect grammar

L60-64. If the compounds were identified in a previous study, why are they being structurally being characterized here?

 L154-155. Substituent at position C-16. It is better to specify what subtituent is a c-16 of compound 1 and how that differs with at in at the same position on compound 3.

L157-158. Explain how hydroxyl substitution at C-4¢¢ and C-8¢¢ of 5 are affecting the activity

L194-1937. Compound 2 and other are being referred as know compounds available literature data

 

L247-261. Why were other fractions not purified? 

Author Response

Dear reviewer:

Thank you very much for the comments, we considered each of the comments point by point, and our response to the comments is listed in the response document, please see the attachment.

Best regards, 

Yani Zhang

Author Response File: Author Response.pdf

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