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Article
Peer-Review Record

Characterization of Metabolic Correlations of Ursodeoxycholic Acid with Other Bile Acid Species through In Vitro Sequential Metabolism and Isomer-Focused Identification

Molecules 2023, 28(12), 4801; https://doi.org/10.3390/molecules28124801
by Wei Li 1, Wei Chen 1, Xiaoya Niu 1, Chen Zhao 2, Pengfei Tu 1, Jun Li 1, Wenjing Liu 3,* and Yuelin Song 1,*
Reviewer 1: Anonymous
Reviewer 2:
Reviewer 3:
Molecules 2023, 28(12), 4801; https://doi.org/10.3390/molecules28124801
Submission received: 29 May 2023 / Revised: 10 June 2023 / Accepted: 13 June 2023 / Published: 16 June 2023
(This article belongs to the Special Issue LC-MS in Bioactive Molecules Study)

Round 1

Reviewer 1 Report

The topic of this manuscript is interesting and fits well the scope of Molecules. The reviewer feels it can be accepted after some minor amendments.

(1) Full  name of UCDA should be indicated in the title.

(2) Change the 1st metabolism to metabolic in the title.

(3)Did the authors detect any species difference in UCDA metabolism between humans and mice?

(4) Could the authors quantify the major metabolite(s)?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The paper is interesting, well written, well structured in all parties. Methodology is adequate and coerent with the endppints. Results and discussion are well defined. The paper is acceptable for publication in the current form

Minor english editing

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

Observations:

-Please edit the abstract: avoid the use of acronyms or include your description.

- Include a general figure (scheme) of the experimental methodology, so that the reader can easily follow the sequence of experiments and assays carried out. Explain briefly in the text.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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