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Molecules
Volume 27
Issue 22
10.3390/molecules27227905
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Review
Peer-Review Record

Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule

Molecules 2022, 27(22), 7905; https://doi.org/10.3390/molecules27227905
by Zeyong Yang 1,*, Wangping Zhang 2, Han Lu 3 and Shu Cai 4,*
Molecules 2022, 27(22), 7905; https://doi.org/10.3390/molecules27227905
Submission received: 19 October 2022 / Revised: 9 November 2022 / Accepted: 11 November 2022 / Published: 15 November 2022
(This article belongs to the Section Chemical Biology)

Round 1

Reviewer 1 Report

The review article "Methylglyoxal in the brain: from glycolytic metabolite to signalling molecule" by Yang et al. is a good topic. Addressing the following suggestions would improve the manuscript presentation. 

Major concerns:
Figure 1 title is Biosynthesis, metabolism and adducts formation. The biosynthesis of MGO is not shown in figure 1. The figure shows that neurons have abundant MGO, leading to many diseases. Describe it clearly. 

Figure 2 shows the biosynthesis of MGO from various sources, a by-product of the MGO, and its connection to the metabolism have shown clearly. Still, the relevant diseases are not shown in the figure, but it was mentioned in the figure title.

The third figure describes the MGO connection with neurological and neurodegenerative diseases but not to diabetics or epigenetics. The figure needs to be vividly explained in the legend. 

Minor concerns:

Page1, paragraph 2, line 2 is not very clear. Mention the homeostasis name.

Page3, paragraph 2, line 1: Mention the MGO involved neurodegenerative diseases names. Correct the irregular font sizes in a few words. The last paragraph of the first line needs to give a full meaning. Complete the sentence where MGO induces apoptosis and mention the citation.  

Page8, 3.2, lines 3-6 are repetitive. 

Mention the C.elegans name uniformly and correct all irregular font sizes throughout the review. 

Author Response

   Please the file named Response to Reviewer 1 point to point.docx

Author Response File: Author Response.pdf

Reviewer 2 Report

1. The author may provide drug-related information regarding MGO side effects.

2. An author should include current research or target regarding MGO.

3. An author should discuss more future research on MGO.

4. The author shall correct some typographical errors in the manuscript

Author Response

Please see the file named Response to Reviewer 2 point to point

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Dear Authors,

The revised manuscript has s improved a lot and gives a good flow to the readers.

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