Next Article in Journal
Effect of Intrahippocampal Administration of α7 Subtype Nicotinic Receptor Agonist PNU-282987 and Its Solvent Dimethyl Sulfoxide on the Efficiency of Hypoxic Preconditioning in Rats
Next Article in Special Issue
The Infestation of Olive Fruits by Bactrocera oleae (Rossi) Modifies the Expression of Key Genes in the Biosynthesis of Volatile and Phenolic Compounds and Alters the Composition of Virgin Olive Oil
Previous Article in Journal
Influence of the Substituents on the Opening of Silylepoxy Alcohols: 5-exo-Cyclization towards Tetrahydrofurans vs. Unexpected Side Reaction Leading to Tetrahydropyrans
Previous Article in Special Issue
Occurrence of Marine Ingredients in Fragrance: Update on the State of Knowledge
 
 
Article

Development of a Continuous System for 2-Phenylethanol Bioproduction by Yeast on Whey Permeate-Based Medium

1
Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland
2
Laboratory of White Biotechnology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Luca Forti
Molecules 2021, 26(23), 7388; https://doi.org/10.3390/molecules26237388
Received: 5 November 2021 / Revised: 26 November 2021 / Accepted: 1 December 2021 / Published: 6 December 2021
(This article belongs to the Collection Recent Advances in Flavors and Fragrances)
2-Phenylethanol (2-PE) is an alcohol with a rosy scent and antimicrobial activity, and therefore, it is widely used in the food and cosmetic industries as an aroma and preservative. This work was aimed to draw up a technology for 2-PE bioproduction on whey permeate, which is waste produced by the dairy industry, rich in lactase and proteins. Its composition makes it a harmful waste to dispose of; however, with a properly selected microorganism, it could be converted to a value-added product. Herein, two yeast Kluyveromyces marxianus strains and one Kluyveromyces lactis, isolated from dairy products, were tested for 2-PE production, firstly on standard media and then on whey permeate based media in batch cultures. Thereafter, the 2-PE bioproduction in a continuous system in a 4.8 L bioreactor was developed, and subsequently, the final product was recovered from culture broth. The results showed that the yield of 2-PE production increased by 60% in the continuous culture compared to batch culture. Together with a notable reduction of chemical oxygen demand for whey permeate, the present study reports a complete, effective, and environmentally friendly strategy for 2-PE bioproduction with a space-time yield of 57.5 mg L−1 h−1. View Full-Text
Keywords: 2-phenylethanol; whey permeate; yeast; Kluyveromyces; continuous culture; batch culture; bioreactor 2-phenylethanol; whey permeate; yeast; Kluyveromyces; continuous culture; batch culture; bioreactor
Show Figures

Graphical abstract

MDPI and ACS Style

Drężek, K.; Kozłowska, J.; Detman, A.; Mierzejewska, J. Development of a Continuous System for 2-Phenylethanol Bioproduction by Yeast on Whey Permeate-Based Medium. Molecules 2021, 26, 7388. https://doi.org/10.3390/molecules26237388

AMA Style

Drężek K, Kozłowska J, Detman A, Mierzejewska J. Development of a Continuous System for 2-Phenylethanol Bioproduction by Yeast on Whey Permeate-Based Medium. Molecules. 2021; 26(23):7388. https://doi.org/10.3390/molecules26237388

Chicago/Turabian Style

Drężek, Karolina, Joanna Kozłowska, Anna Detman, and Jolanta Mierzejewska. 2021. "Development of a Continuous System for 2-Phenylethanol Bioproduction by Yeast on Whey Permeate-Based Medium" Molecules 26, no. 23: 7388. https://doi.org/10.3390/molecules26237388

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop