Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease
Abstract
:1. Introduction
2. Familial AD and Genetics
3. Presenilin and the γ-Secretase Complex
4. Chemical Probes
5. Structural Probes
6. Functional Probes
7. γ-Secretase Inhibitors: Therapeutic Potential
8. γ-Secretase Modulators: Therapeutic Potential
9. Summary and Perspective
Funding
Conflicts of Interest
References
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Wolfe, M.S. Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease. Molecules 2021, 26, 388. https://doi.org/10.3390/molecules26020388
Wolfe MS. Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease. Molecules. 2021; 26(2):388. https://doi.org/10.3390/molecules26020388
Chicago/Turabian StyleWolfe, Michael S. 2021. "Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease" Molecules 26, no. 2: 388. https://doi.org/10.3390/molecules26020388