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Review

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
Academic Editor: Laura De Martino
Molecules 2021, 26(14), 4212; https://doi.org/10.3390/molecules26144212
Received: 16 June 2021 / Revised: 5 July 2021 / Accepted: 8 July 2021 / Published: 11 July 2021
(This article belongs to the Special Issue Natural Products in Asia)
Oxyresveratrol has recently attracted much research attention due to its simple chemical structure and diverse therapeutic potentials. Previous reviews describe the chemistry and biological activities of this phytoalexin, but additional coverage and greater accessibility are still needed. The current review provides a more comprehensive summary, covering research from 1955 to the present year. Oxyresveratrol occurs in both gymnosperms and angiosperms. However, it has never been reported in plants in the subclass Sympetalae, and this point might be of both chemotaxonomic and biosynthetic importance. Oxyresveratrol can be easily obtained from plant materials by conventional methods, and several systems for both qualitative and quantitative analysis of oxyresveratrol contents in plant materials and plant products are available. Oxyresveratrol possesses diverse biological and pharmacological activities such as the inhibition of tyrosinase and melanogenesis, antioxidant and anti-inflammatory activities, and protective effects against neurological disorders and digestive ailments. However, the unfavorable pharmacokinetic properties of oxyresveratrol, including low water solubility and poor oral availability and stability, have posed challenges to its development as a useful therapeutic agent. Recently, several delivery systems have emerged, with promising outcomes that may improve chances for the clinical study of oxyresveratrol. View Full-Text
Keywords: oxyresveratrol; synthesis; culture; tyrosinase; antioxidant; antiviral; neuroprotective; anticancer; metabolism; delivery system oxyresveratrol; synthesis; culture; tyrosinase; antioxidant; antiviral; neuroprotective; anticancer; metabolism; delivery system
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MDPI and ACS Style

Likhitwitayawuid, K. Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems. Molecules 2021, 26, 4212. https://doi.org/10.3390/molecules26144212

AMA Style

Likhitwitayawuid K. Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems. Molecules. 2021; 26(14):4212. https://doi.org/10.3390/molecules26144212

Chicago/Turabian Style

Likhitwitayawuid, Kittisak. 2021. "Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems" Molecules 26, no. 14: 4212. https://doi.org/10.3390/molecules26144212

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