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Article

Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Raluca Maria Pop, Ada Popolo and Stefan Cristian Vesa
Molecules 2021, 26(14), 4210; https://doi.org/10.3390/molecules26144210
Received: 17 June 2021 / Revised: 7 July 2021 / Accepted: 7 July 2021 / Published: 11 July 2021
Coptisine is the major bioactive protoberberine alkaloid found in Rhizoma Coptidis. Coptisine reduces inflammatory responses and improves glucose tolerance; nevertheless, whether coptisine has vasoprotective effect in diabetes is not fully characterized. Conduit arteries including aortas and carotid arteries were obtained from male C57BL/6J mice for ex vivo treatment with risk factors (high glucose or tunicamycin) and coptisine. Some arterial rings were obtained from diabetic mice, which were induced by high-fat diet (45% kcal% fat) feeding for 6 weeks combined with a low-dose intraperitoneal injection of streptozotocin (120 mg/kg). Functional studies showed that coptisine protected endothelium-dependent relaxation in aortas against risk factors and from diabetic mice. Coptisine increased phosphorylations of AMPK and eNOS and downregulated the endoplasmic reticulum (ER) stress markers as determined by Western blotting. Coptisine elevates NO bioavailability and decreases reactive oxygen species level. The results indicate that coptisine improves vascular function in diabetes through suppression of ER stress and oxidative stress, implying the therapeutic potential of coptisine to treat diabetic vasculopathy. View Full-Text
Keywords: coptisine; diabetes; endoplasmic reticulum stress; endothelial dysfunction; oxidative stress coptisine; diabetes; endoplasmic reticulum stress; endothelial dysfunction; oxidative stress
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MDPI and ACS Style

Zhou, Y.; Zhou, C.; Zhang, X.; Vong, C.T.; Wang, Y.; Cheang, W.S. Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress. Molecules 2021, 26, 4210. https://doi.org/10.3390/molecules26144210

AMA Style

Zhou Y, Zhou C, Zhang X, Vong CT, Wang Y, Cheang WS. Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress. Molecules. 2021; 26(14):4210. https://doi.org/10.3390/molecules26144210

Chicago/Turabian Style

Zhou, Yan, Chunxiu Zhou, Xutao Zhang, Chi Teng Vong, Yitao Wang, and Wai San Cheang. 2021. "Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress" Molecules 26, no. 14: 4210. https://doi.org/10.3390/molecules26144210

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