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Open AccessArticle

Bioassay-Guided Isolation of Antiproliferative Compounds from Limbarda crithmoides (L.) Dumort

1
Department of Medicine, Foligno Nursing School, University of Perugia, 06034 Foligno, Italy
2
Department of Biomolecular Sciences, Section of Biochemistry and Biotechnology, University of Urbino, 61029 Urbino, Italy
3
Department of Medicine, Section of Pharmacology, University of Perugia, 06132 Perugia, Italy
4
Department of Pharmaceutical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Luisella Verotta
Molecules 2020, 25(8), 1893; https://doi.org/10.3390/molecules25081893
Received: 4 March 2020 / Revised: 16 April 2020 / Accepted: 17 April 2020 / Published: 20 April 2020
(This article belongs to the Special Issue Natural Products in Italy)
Limbarda crithmoides (L.) Dumort (Asteraceae) n-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate (1) and 10-acetoxy-9-chloro-8,9-dehydrothymol (2), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-dependent inhibition of cell proliferation. View Full-Text
Keywords: Inula crithmoides; Limbarda crithmoides; Asteraceae; antiproliferative activity; OCI-AML3 Inula crithmoides; Limbarda crithmoides; Asteraceae; antiproliferative activity; OCI-AML3
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MDPI and ACS Style

Adorisio, S.; Giamperi, L.; Bucchini, A.E.A.; Delfino, D.V.; Marcotullio, M.C. Bioassay-Guided Isolation of Antiproliferative Compounds from Limbarda crithmoides (L.) Dumort. Molecules 2020, 25, 1893.

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