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Open AccessArticle

Antiproliferative Properties of Papaver rhoeas Ovule Extracts and Derived Fractions Tested on HL60 Leukemia Human Cells

1
Department for the Innovation in Biological, Agro-food and Forestal systems, Tuscia University, 01100 Viterbo, Italy
2
Department of Drug Chemistry and Technology, Sapienza University, 00100 Rome, Italy
3
Center of Electron Microscopy, Tuscia University, 01100 Viterbo, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Carla Marcotullio
Molecules 2020, 25(8), 1850; https://doi.org/10.3390/molecules25081850
Received: 14 March 2020 / Revised: 9 April 2020 / Accepted: 14 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Natural Products in Italy)
Papaver rhoeas plant is common in many regions worldwide and contributes to the landscape with its red flower. In the present study we first carried out morphological investigation by optical and scanning electron microscopy of the ovules within the ovary. After ovules’ isolation we prepared extracts to test possible cytotoxic activities on HL60 leukemia human cells and investigated the extracts using thin-layer chromatography (TLC) and gas-chromatography/mass spectrometry (GC-MS). P. rhoeas ovules showed an elongated, round shape and the presence of ordered sculptures on the ovule surface. The ovule extracts showed cytotoxic activity on HL60 human cells mainly found in some TLC-isolated spots. Compounds consisting of active spots were identified by GC-MS investigations. Our findings on the P. rhoeas ovule compounds open perspectives for further investigations of TLC-isolated spots on other human cancer cell lines. View Full-Text
Keywords: Papaver rhoeas; ovules; plant compounds; cytotoxic activity; GC-MS Papaver rhoeas; ovules; plant compounds; cytotoxic activity; GC-MS
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Ovidi, E.; Laghezza Masci, V.; Garzoli, S.; Gambellini, G.; Keita, S.V.; Zago, D.; Turchetti, G.; Modesti, L.; Tiezzi, A. Antiproliferative Properties of Papaver rhoeas Ovule Extracts and Derived Fractions Tested on HL60 Leukemia Human Cells. Molecules 2020, 25, 1850.

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