Next Article in Journal
Proteomic Characterisation of Lupin (Lupinus angustifolius) Milk as Influenced by Extraction Techniques, Seed Coat and Cultivars
Previous Article in Journal
Understanding the Hsp90 N-Terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922)
Open AccessArticle

Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis

1
Pharmacology and Toxicology Department, College of Pharmacy, Prince Sattam bin Abdulaziz University, AlKharj 11942, Saudi Arabia
2
Pharmacognosy Department, College of Pharmacy, Prince Sattam bin Abdulaziz University, AlKharj 11942, Saudi Arabia
3
Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria 21215, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(8), 1786; https://doi.org/10.3390/molecules25081786
Received: 23 March 2020 / Revised: 8 April 2020 / Accepted: 11 April 2020 / Published: 13 April 2020
(This article belongs to the Section Medicinal Chemistry)
Cardiac hypertrophy is an independent risk factor of many cardiovascular diseases. Several cardiovascular protective properties of Cymbopogon proximus have been reported. However, no reports investigating the direct effect of C. proximus essential oil on the heart are available. The goal of this study was to explore the cardioprotective effect of C. proximus on cardiac hypertrophy and fibrosis. Male albino rats were administered C. proximus essential oil in the presence or absence of hypertrophic agonist isoproterenol. Cardiac hypertrophy and fibrosis were assessed using real-time polymerase chain reaction (PCR) and histological examination. Pre- treatment of rats with C. proximus decreased the ratio of heart weight to body weight and gene expression of hypertrophy markers atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and β-myosin heavy chain (β-MHC), which were induced by isoproterenol. Moreover, C. proximus prevented the increase in gene expression of fibrosis markers procollagen I and procollagen III and alleviated the collagen volume fraction caused by isoproterenol. The pre- treatment with C. proximus essential oil conferred cardio-protection against isoproterenol- induced cardiac hypertrophy and fibrosis. View Full-Text
Keywords: cardiac fibrosis; cardiac hypertrophy; cardiac remodeling; Cymbopogon proximus; isoproterenol cardiac fibrosis; cardiac hypertrophy; cardiac remodeling; Cymbopogon proximus; isoproterenol
Show Figures

Figure 1

MDPI and ACS Style

Althurwi, H.N.; Abdel-Kader, M.S.; Alharthy, K.M.; Salkini, M.A.; Albaqami, F.F. Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis. Molecules 2020, 25, 1786.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop