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Article

Chemical Analysis of Minor Bioactive Components and Cannabidiolic Acid in Commercial Hemp Seed Oil

1
Department of Pharmacy, University of Naples “Federico II”, 80131 Naples, Italy
2
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
3
Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples “Federico II”, CEINGE-Biotecnologie Avanzate, 80131 Naples, Italy
4
Health Education and Sustainable Development, “Federico II” University, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Laura De Martino and Derek J. McPhee
Molecules 2020, 25(16), 3710; https://doi.org/10.3390/molecules25163710
Received: 14 July 2020 / Revised: 2 August 2020 / Accepted: 12 August 2020 / Published: 14 August 2020
(This article belongs to the Special Issue Industrial Hemp Chemistry and Nutraceutical Perspectives)
Although hemp seed (HS) oil is characterized by more than 80% polyunsaturated fatty acids (PUFAs), a very high ω-6-to-ω-3 ratio is not a popular commodity. The aim of this work was to provide useful data about the bioactive components and cannabidiolic acid content in thirteen different commercial hemp seed oils. The investigated HS oils showed a good ω-6/ω-3 ratio, ranging from 1.71 to 2.27, massively differed in their chlorophylls (0.041–2.64 µg/g) and carotenoids contents (0.29–1.73 µg/g), as well as in total phenols (22.1–160.8 mg Gallic Acid Equivalents (GAE)/g) and tocopherols (3.47–13.25 mg/100 g). Since the high content of PUFAs in HS oils, photo-oxidative stability was investigated by determining the Thiobarbituric Acid Reactive Substances (TBARS) assay and extinction coefficient K232 and K270 after the photo-oxidative test. The percentage of increase in K232 and K270 ranged from 1.2 to 8.5% and from 3.7 to 26.0%, respectively, indicating good oxidative stability, but TBARS showed a 1.5- to 2.5-fold increase in oxidative behavior when compared to the initial values. Therefore, the diversity in bioactive compounds in HS oils, and their high nutritional value, suggest the need for a disciplinary booklet that well defines agronomic and post-harvest management conditions for achieving a good food objective. View Full-Text
Keywords: hemp seed oil; bioactive compounds; polyphenols; ω-6/ω-3 ratio; tocopherols; chlorophylls; carotenoids; cannabidiolic acid hemp seed oil; bioactive compounds; polyphenols; ω-6/ω-3 ratio; tocopherols; chlorophylls; carotenoids; cannabidiolic acid
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MDPI and ACS Style

Izzo, L.; Pacifico, S.; Piccolella, S.; Castaldo, L.; Narváez, A.; Grosso, M.; Ritieni, A. Chemical Analysis of Minor Bioactive Components and Cannabidiolic Acid in Commercial Hemp Seed Oil. Molecules 2020, 25, 3710. https://doi.org/10.3390/molecules25163710

AMA Style

Izzo L, Pacifico S, Piccolella S, Castaldo L, Narváez A, Grosso M, Ritieni A. Chemical Analysis of Minor Bioactive Components and Cannabidiolic Acid in Commercial Hemp Seed Oil. Molecules. 2020; 25(16):3710. https://doi.org/10.3390/molecules25163710

Chicago/Turabian Style

Izzo, Luana, Severina Pacifico, Simona Piccolella, Luigi Castaldo, Alfonso Narváez, Michela Grosso, and Alberto Ritieni. 2020. "Chemical Analysis of Minor Bioactive Components and Cannabidiolic Acid in Commercial Hemp Seed Oil" Molecules 25, no. 16: 3710. https://doi.org/10.3390/molecules25163710

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