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Open AccessArticle

Comparative Effects of Dietary Hemp and Poppy Seed Oil on Lipid Metabolism and the Antioxidant Status in Lean and Obese Zucker Rats

1
Department of Biological Function of Foods, Institute of Animal Reproduction and Food Research, Division of Food Science, Tuwima 10, 10-748 Olsztyn, Poland
2
Department of Chemistry and Biodynamics of Food, Institute of Animal Reproduction and Food Research, Division of Food Science, Tuwima 10, 10-748 Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Severina Pacifico
Molecules 2020, 25(12), 2921; https://doi.org/10.3390/molecules25122921
Received: 25 May 2020 / Revised: 19 June 2020 / Accepted: 25 June 2020 / Published: 25 June 2020
(This article belongs to the Special Issue Industrial Hemp Chemistry and Nutraceutical Perspectives)
The objective of this study was to compare the effects of the dietary inclusion of hemp seed oil (HO) and poppy seed oil (PO) on the lipid metabolism and antioxidant status of lean and genetically obese Zucker rats. The rats were fed a control diet for laboratory rodents or a modification with HO or PO. Both oils reduced body and epididymal fat and liver cholesterol levels and promoted oxidative stress in the liver of obese rats. The HO reduced plasma triglycerides and had a stronger liver cholesterol-lowering effect in obese rats than PO. In the lean rats, HO and PO had no effects on the body fat content, plasma lipid profile, or lipid metabolism in the liver. HO considerably elevated the content of α-linolenic acid in the liver and increased the liver ratio of reduced glutathione (GSH)/oxidized glutathione (GSSG) in the lean rats. In conclusion, the regular consumption of both oils increases the accumulation of essential fatty acids in the liver of healthy animals, whilst not having any adverse effects on the body, whereas in genetically obese rats, the effects of both dietary oils on the lipid metabolism and antioxidant status are unequivocal and only partially beneficial. View Full-Text
Keywords: unsaturated fatty acids; obesity; lipid profile; liver disorders; oxidative stress; Zucker rats unsaturated fatty acids; obesity; lipid profile; liver disorders; oxidative stress; Zucker rats
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MDPI and ACS Style

Fotschki, B.; Opyd, P.; Juśkiewicz, J.; Wiczkowski, W.; Jurgoński, A. Comparative Effects of Dietary Hemp and Poppy Seed Oil on Lipid Metabolism and the Antioxidant Status in Lean and Obese Zucker Rats. Molecules 2020, 25, 2921. https://doi.org/10.3390/molecules25122921

AMA Style

Fotschki B, Opyd P, Juśkiewicz J, Wiczkowski W, Jurgoński A. Comparative Effects of Dietary Hemp and Poppy Seed Oil on Lipid Metabolism and the Antioxidant Status in Lean and Obese Zucker Rats. Molecules. 2020; 25(12):2921. https://doi.org/10.3390/molecules25122921

Chicago/Turabian Style

Fotschki, Bartosz; Opyd, Paulina; Juśkiewicz, Jerzy; Wiczkowski, Wiesław; Jurgoński, Adam. 2020. "Comparative Effects of Dietary Hemp and Poppy Seed Oil on Lipid Metabolism and the Antioxidant Status in Lean and Obese Zucker Rats" Molecules 25, no. 12: 2921. https://doi.org/10.3390/molecules25122921

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