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Article

Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced Diabetic Rats

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Derek J. McPhee and Fernando Albericio
Molecules 2019, 24(3), 558; https://doi.org/10.3390/molecules24030558
Received: 30 November 2018 / Revised: 11 January 2019 / Accepted: 1 February 2019 / Published: 3 February 2019
(This article belongs to the Special Issue Bioactive Peptides—From Therapy to Nutrition)
The study was aimed to determine whether treatment with oat oligopeptides (OOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in Sprague–Dawley (SD) rats. Diabetic SD rats modeling by a joint effect of high-calorie diet for 45 days and twice intraperitoneal injection of 30 mg/kg streptozotocin at one-week interval were observed with or without OOPs administration (0.25, 0.50, 1.00, and 2.00 g/kg Body Weight) for 12 weeks. Fasting blood glucose (FBG), oral glucose test tolerance (OGTT), serum insulin, level of antioxidant, and hepatic enzymes were measured. In addition, frequency of micturition was recorded in this study for the first time. It was observed that the administration of OOPs (2.00 g/kg Body Weight) resulted in a significant decrease (p < 0.05) in FBG since 6th week and a significant decrease (p < 0.05) in the OGTT-AUC on 6th and 10th week. In addition, the administration of OOPs (2.00 g/kg Body Weight) reduced HOMA-IR index and 24-h urine volume significantly (p < 0.05) whereas increased SOD activity significantly (p < 0.05). These results suggested that OOPs may have a hypoglycemic effect in diabetic rats. View Full-Text
Keywords: oat oligopeptides; hypoglycemic effect; oral glucose tolerance test oat oligopeptides; hypoglycemic effect; oral glucose tolerance test
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MDPI and ACS Style

Wang, J.-b.; Liu, X.-r.; Liu, S.-q.; Mao, R.-x.; Hou, C.; Zhu, N.; Liu, R.; Ma, H.-j.; Li, Y. Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced Diabetic Rats. Molecules 2019, 24, 558. https://doi.org/10.3390/molecules24030558

AMA Style

Wang J-b, Liu X-r, Liu S-q, Mao R-x, Hou C, Zhu N, Liu R, Ma H-j, Li Y. Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced Diabetic Rats. Molecules. 2019; 24(3):558. https://doi.org/10.3390/molecules24030558

Chicago/Turabian Style

Wang, Jun-bo, Xin-ran Liu, Si-qi Liu, Rui-xue Mao, Chao Hou, Na Zhu, Rui Liu, Hui-juan Ma, and Yong Li. 2019. "Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced Diabetic Rats" Molecules 24, no. 3: 558. https://doi.org/10.3390/molecules24030558

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