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Open AccessArticle

Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles

Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(23), 4224; https://doi.org/10.3390/molecules24234224
Received: 26 September 2019 / Revised: 29 October 2019 / Accepted: 30 October 2019 / Published: 20 November 2019
(This article belongs to the Special Issue Sustainable Catalysis)
An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures. View Full-Text
Keywords: imidazolium chloride; amino protection; Michael addition reaction; amino deprotection; solvent-free; seven-membered ring imidazolium chloride; amino protection; Michael addition reaction; amino deprotection; solvent-free; seven-membered ring
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MDPI and ACS Style

Dai, Z.; Tian, Q.; Li, Y.; Shang, S.; Luo, W.; Wang, X.; Li, D.; Zhang, Y.; Li, Z.; Yuan, J. Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles. Molecules 2019, 24, 4224.

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