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Effect of the Chemical Composition of Free-Terpene Hydrocarbons Essential Oils on Antifungal Activity
Open AccessArticle

Synergistic/Antagonistic Potential of Natural Preparations Based on Essential Oils Against Streptococcus mutans from the Oral Cavity

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Faculty of Dental Medicine, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timişoara, Romania
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Faculty of Agriculture, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timişoara, Calea Aradului No. 119, 300641 Timişoara, Romania
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Faculty of Veterinary Medicine, Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timişoara, Calea Aradului No. 119, 300641 Timişoara, Romania
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Author to whom correspondence should be addressed.
Academic Editor: Daniela Rigano
Molecules 2019, 24(22), 4043; https://doi.org/10.3390/molecules24224043
Received: 16 September 2019 / Revised: 3 November 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
The present paper addresses a thematic of interest in preventive dental medicine, namely the possibility of using essential oils (EOs) for the inhibition of the development of Streptococcus mutans (S. mutans) in the oral cavity, as a viable alternative to chemical products with protective role in oral health. For this purpose, four EOs (cinnamon, clove, bergamote, and orange) were chemically characterized by gas chromatography coupled with mass spectrometry (GC-MS) and in vitro tested against S. mutans (ATCC 25175). The results obtained revealed the antibacterial effect on S. mutans exercised by the essential oils of clove (CLEO), bergamote (BEO), and orange (OEO), which were included in the production of natural emulsion-type preparations with application in dental medicine. In order to highlight the synersistic/antagonistic effects generated by the chemical constituent of essential oils, binary and tertiary emulsions were prepared and used in saliva-enhanced medium against S. mutans. The saliva tests proved the synergistic effect exercised by the active components of EOs tested from tertiary emulsions, which cause an inhibition of the development of S. mutans in oral cavities. View Full-Text
Keywords: gas chromatography-mass spectrometry (GC-MS); orange essential oil; bergamot essential oil; cloves essential oil gas chromatography-mass spectrometry (GC-MS); orange essential oil; bergamot essential oil; cloves essential oil
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MDPI and ACS Style

Alexa, V.T.; Galuscan, A.; Popescu, I.; Tirziu, E.; Obistioiu, D.; Floare, A.D.; Perdiou, A.; Jumanca, D. Synergistic/Antagonistic Potential of Natural Preparations Based on Essential Oils Against Streptococcus mutans from the Oral Cavity. Molecules 2019, 24, 4043.

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