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The Dynamics of Hole Transfer in DNA

Dipartimento di Chimica e Biologia “A. Zambelli”, Università di Salerno, via Giovanni Paolo II, 132, I-84084 Fisciano (SA), Italy
Author to whom correspondence should be addressed.
Molecules 2019, 24(22), 4044;
Received: 28 September 2019 / Revised: 31 October 2019 / Accepted: 2 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Biomimetic Radical Chemistry and Applications)
High-energy radiation and oxidizing agents can ionize DNA. One electron oxidation gives rise to a radical cation whose charge (hole) can migrate through DNA covering several hundreds of Å, eventually leading to irreversible oxidative damage and consequent disease. Understanding the thermodynamic, kinetic and chemical aspects of the hole transport in DNA is important not only for its biological consequences, but also for assessing the properties of DNA in redox sensing or labeling. Furthermore, due to hole migration, DNA could potentially play an important role in nanoelectronics, by acting as both a template and active component. Herein, we review our work on the dynamics of hole transfer in DNA carried out in the last decade. After retrieving the thermodynamic parameters needed to address the dynamics of hole transfer by voltammetric and spectroscopic experiments and quantum chemical computations, we develop a theoretical methodology which allows for a faithful interpretation of the kinetics of the hole transport in DNA and is also capable of taking into account sequence-specific effects. View Full-Text
Keywords: DNA oxidation; DNA hole transfer; DNA; quantum dynamics; electron transfer; charge transfer DNA oxidation; DNA hole transfer; DNA; quantum dynamics; electron transfer; charge transfer
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MDPI and ACS Style

Peluso, A.; Caruso, T.; Landi, A.; Capobianco, A. The Dynamics of Hole Transfer in DNA. Molecules 2019, 24, 4044.

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