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Open AccessArticle

Antioxidant, Xanthine Oxidase, α-Amylase and α-Glucosidase Inhibitory Activities of Bioactive Compounds from Rumex crispus L. Root

1
Center for Research and Technology Transfer (CRETECH), Vietnam Academy of Sciences and Technology, Hanoi 10072, Vietnam
2
Graduate School for International Development and Cooperation (IDEC), Hiroshima University, Higashi-Hiroshima 739-8529, Japan
3
Research Center for Appropriate Technology, Indonesian Institute of Sciences, Subang, 41213, Indonesia
4
Department of Chemistry, College of Science and Mathematics, Mindanao State University - Iligan Institute of Technology, Iligan 9200, Philippines
*
Author to whom correspondence should be addressed.
Academic Editors: Raffaele Capasso and Lorenzo Di Cesare Mannelli
Molecules 2019, 24(21), 3899; https://doi.org/10.3390/molecules24213899
Received: 19 September 2019 / Revised: 19 October 2019 / Accepted: 22 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
The root of Rumex crispus L. has been shown to possess anti-gout and anti-diabetic properties, but the compounds responsible for these pharmaceutical effects have not yet been reported. In this study, we aimed to isolate and purify active components from the root of R. crispus, and to evaluate their anti-radical, anti-gout and anti-diabetic capacities. From the ethyl acetate (EtOAc) extract, two compounds, chrysophanol (1) and physcion (2), were isolated by column chromatography with an elution of hexane and EtOAc at a 9:1 ratio. Their structures were identified by spectrometric techniques including gas chromatography-mass spectrometry (GC-MS), electrospray ionization-mass spectrometry (ESI-MS), X-ray diffraction analyses and nuclear magnetic resonance (NMR). The results of bioassays indicated that (1) showed stronger activities than (2). For antioxidant activity, (1) and (2) exhibited remarkable DPPH radical scavenging capacity (IC50 = 9.8 and 12.1 µg/mL), which was about two times stronger than BHT (IC50 = 19.4 µg/mL). The anti-gout property of (1) and (2) were comparable to the positive control allopurinol, these compounds exerted strong inhibition against the activity of xanthine oxidase (IC50 = 36.4 and 45.0 µg/mL, respectively). In the anti-diabetic assay, (1) and (2) displayed considerable inhibitory ability on α-glucosidase, their IC50 values (IC50 = 20.1 and 18.9 µg/mL, respectively) were higher than that of standard acarbose (IC50 = 143.4 µg/mL). Findings of this study highlight that (1) and (2) may be promising agents to treat gout and diabetes, which may greatly contribute to the medicinal properties of Rumex crispus root. View Full-Text
Keywords: bioactive compound; anti-radical; anti-gout; anti-diabetic; Rumex crispus; chrysophanol; physcion bioactive compound; anti-radical; anti-gout; anti-diabetic; Rumex crispus; chrysophanol; physcion
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Minh, T.N.; Van, T.M.; Andriana, Y.; Vinh, L.T.; Hau, D.V.; Duyen, D.H.; Guzman-Gelani, C. Antioxidant, Xanthine Oxidase, α-Amylase and α-Glucosidase Inhibitory Activities of Bioactive Compounds from Rumex crispus L. Root. Molecules 2019, 24, 3899.

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