Next Article in Journal
The Complete Plastid Genome of Magnolia zenii and Genetic Comparison to Magnoliaceae species
Next Article in Special Issue
UV Photoprotection, Cytotoxicity and Immunology Capacity of Red Algae Extracts
Previous Article in Journal
Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists
Previous Article in Special Issue
Agar Extraction By-Products from Gelidium sesquipedale as a Source of Glycerol-Galactosides
Article Menu
Issue 2 (January-2) cover image

Export Article

Open AccessArticle
Molecules 2019, 24(2), 260; https://doi.org/10.3390/molecules24020260

Brown Seaweed Egregia menziesii’s Cytotoxic Activity against Brain Cancer Cell Lines

1
Instituto de Investigaciones Oceanológicas, Universidad Autónoma de Baja California, Ensenada, Baja California 22860, Mexico
2
Programa de Doctorado en Ciencias Biomédicas, Universidad Veracruzana, Xalapa, Veracruz 91190, Mexico
3
Instituto de Ciencias Básicas, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n. Col., Industrial Ánimas, Xalapa, Veracruz 91190, Mexico
4
Instituto de Salud Pública, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n, Col., Industrial Ánimas, Xalapa, Veracruz 91190, Mexico
5
Centro de Investigaciones Biomédicas, Universidad Veracruzana. Av. Dr. Luis Castelazo Ayala s/n. Col., Industrial Ánimas, Xalapa, Veracruz 91190, Mexico
6
Laboratorio de Genómica Humana, Facultad de Medicina, Universidad Veracruzana, Médicos y Odontólogos S/N, Col., Unidad del Bosque, Xalapa, Veracruz 91010, Mexico
7
Laboratorio de Neurotoxicología, Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07300, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: Natália Martins and Laurent Vandanjon
Received: 13 December 2018 / Revised: 7 January 2019 / Accepted: 9 January 2019 / Published: 11 January 2019
Full-Text   |   PDF [1213 KB, uploaded 11 January 2019]   |  
  |   Review Reports

Abstract

Brown seaweeds contain bioactive compounds that show anti-tumorigenic effects. These characteristics have been repeatedly observed in the Lessoniaceae family. Egregia menziesii, a member of this family, is distributed in the North Pacific and its properties have been barely studied. We evaluated herein the cytotoxic and anti-proliferative activity of extracts of this seaweed, through toxicity assay in Artemia salina and lymphocytes, and MTT proliferation assay, in Bergmann glia cells, 3T3-L1 and brain cancer cell lines. E. menziesii’s extracts inhibited the spread of all the tested cell lines. The hexane extract showed the highest cytotoxic activity, while the methanol extract was moderately cytotoxic. Interestingly, seaweed extracts displayed a selective inhibition pattern. These results suggest that E. menziesii’s extracts might be good candidates for cancer prevention and the development of novel chemotherapies due to its highest cytotoxicity in transformed cells compare to glia primary cultures. View Full-Text
Keywords: marine algae; cancer; seaweeds properties; anti-tumor activity; cell-toxicity marine algae; cancer; seaweeds properties; anti-tumor activity; cell-toxicity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Olivares-Bañuelos, T.; Gutiérrez-Rodríguez, A.G.; Méndez-Bellido, R.; Tovar-Miranda, R.; Arroyo-Helguera, O.; Juárez-Portilla, C.; Meza-Menchaca, T.; Aguilar-Rosas, L.E.; Hernández-Kelly, L.C.R.; Ortega, A.; Zepeda, R.C. Brown Seaweed Egregia menziesii’s Cytotoxic Activity against Brain Cancer Cell Lines. Molecules 2019, 24, 260.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top