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Flavonoids from Brazilian Cerrado: Biosynthesis, Chemical and Biological Profile

1
Laboratório de Pesquisa em Biodiversidade (LaPeBio), Centro Universitário de Anápolis–UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil
2
Câmpus de Ciências Exatas e Tecnológicas, Universidade Estadual de Goiás, Anápolis 75132-400, Goiás, Brazil
3
Laboratory of Cheminformatics (LabChemIn), Centro Universitário de Anápolis–UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil
4
Laboratório de Novos Materiais, Centro Universitário de Anápolis–UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil
5
Laboratório de Pesquisas Avançadas e Geoprocesamento (LaPAGeo), Centro Universitário de Anápolis–UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil
6
Laboratório de História Ambiental do Cerrado, Centro Universitário de Anápolis–UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Molecules 2019, 24(16), 2891; https://doi.org/10.3390/molecules24162891
Received: 25 March 2019 / Accepted: 3 April 2019 / Published: 9 August 2019
(This article belongs to the Section Natural Products Chemistry)
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PDF [2316 KB, uploaded 9 August 2019]
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Abstract

Flavonoids are highly bioactive compounds with very low toxicity, which makes them attractive starting points in drug discovery. This study aims to provide information on plant species containing flavonoids, which are found in the Brazilian Cerrado. First, we present the characterization and plant diversity with emphasis on the families of flavonoid-producing plants, and then we describe the phenylpropanoid pathway which represents the flavonoids’ main route biosynthesis—generally conserved in all species. Chemical structures and biological activities of flavonoids isolated from the Cerrado’s plant species are also described based on examples from the relevant literature studies. Finally, research on the biodiversity of the Cerrado biome should be encouraged, due to the discovery of new sources of flavonoids which can provide several benefits to human health and the possibility of developing new drugs by the pharmaceutical industry. View Full-Text
Keywords: biodiversity; Brazilian Cerrado; biosynthesis; flavonoids biodiversity; Brazilian Cerrado; biosynthesis; flavonoids
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MDPI and ACS Style

Peixoto, J.C.; Neves, B.J.; Vasconcelos, F.G.; Napolitano, H.B.; Barbalho, M.G.S.; Silva, S.D.; Rosseto, L.P. Flavonoids from Brazilian Cerrado: Biosynthesis, Chemical and Biological Profile. Molecules 2019, 24, 2891.

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